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At the time when he developed the details
of the concept of allostery, Jacques Monod had a central role
in the creation of the Centre Royaumont pour une Science de l'Homme,
with the idea to reconcile biology and neurosciences. His ultimate
view was that the link between both was ethical: knowledge carries
its own ethics. Massimo Piattelli-Palmarini, who had stayed for
some time in his laboratory was most interested in science and
philosophy, and it was natural for Monod to ask him to organise
a group of reflection which would associate scientists for a
variety of disciplines, with a strong emphasis on philosophy
of sciences. This led to the creation of the Centre, initially
with Jean-Pierre Changeux, François Dell, Jacques Mehler and
Dan Sperber. The Abbey of Royaumont had long been a site where
intellectuals and artists could convey and organise meetings
where discussions went on, in the spirit of the Middle Ages disputatii.
Together with Konstanty “Kot” Jeleński (1922-1987)
I was asked by Monod to develop new programmes aimed at understanding
the relationships between the human body, brain in particular,
and the most evolved and "abstract"
features of human behaviour.
When the Centre closed I maintained for
some time a working seminar on memory and learning, every wednesday
afternoon at the conference room of the Institut
de Biologie Physico-Chimique. This seminar stopped in 1978
but eventually started again in 1990 at the Institut Pasteur
de Paris as a seminar in philosophy of sciences, initially discussing presocratic
philosophy.
In between, much of the previous programme had been reactivated
via the creation of Fermo's Biennial Encounters, with the historian Ruggiero
Romano (1923-2002) and the support of the Foundation
Einaudi (developing the Enciclopedia Einaudi, with Fernando
Gil (1937-2006)), and
a research programme of anthropology of the west by non-westerners,
inspired by our reflection and starting in West Africa with Alain
Le Pichon, and later developed in China under the name Transcultura,
after a successful experience held by Umberto Eco – who had been
previously involved in the last programme of the CRSH – at the
University of Bologna. A first conference was held in Guangzhou
in 1990, on the
status of science and technology
in the western world and in China. The seminar went on at
the Department of Mathematics at the University of Hong Kong
(2000-2003) and it is now an open E-seminar,
working on information and the synthesis of life.
In parallel with my work as one of the coordinators of the CRSH
I created at the Institut de Biologie Physico-Chimique, with
the mathematician Philippe Courrège, a working seminar that ran
every wednesday afternoon at the conference room of the third
floor, rue Pierre Curie, next to the Institut Henri Poincaré.
The Cercle Polivanov (centre de poétique comparée) developed
there around Jacques
Roubaud, Pierre
Lusson, Marcel
Benabou,
Philippe
Courrège, Mitsou
Ronat (1946 - 1984) and many others and
we had close contacts with their work, and the journal Change (published
by Seghers). Initially we had chosen to work on the mathematical
formalisation of selective theories, initially at the molecular
level. After a conversation I had with Jean-Pierre Changeux,
we shifted to the analysis of selective theories applied to learning
and memory, and beside the core group formed with Philippe Courrège,
Jean-Pierre Changeux and many mathematicians came on a regular
basis to participate to our seminar (François Blanchard, Alain
Chenciner, Jean-Michel Lasry, Pierre Lusson, Gabriel Ruget, Bernard
Saint-Loup, and even Benoît Mandelbrot; I probably forgot some
of the participants). This seminar lasted from 1972 to 1976 on
a regular basis, then came slowly to an end, as the interests
of its actors began to diverge. Several publications were derived
from this work.
The seminar was initiated again after several attempts under
different covers, the biennial Fermo encounters, then a transcultural
study of the west by non-westerners (1988-present), and finally
via a seminar in my laboratory (Regulation of Gene Expression,
1990-2000), then a working seminar at the Department
of Mathematics of the University of Hong Kong (2000-2003), transformed into
an ongoing E-seminar, the "causeries
du jeudi" (2003-present).
JP Changeux,
P Courrège, A Danchin
A theory of the epigenesis of neuronal networks by selective
stabilization of synapses
Proc Natl Acad Sci U S A (1973) 70: 2974-2978 
| Abstract: A
formalism is introduced to represent the connective organization
of an evolving neuronal network and the effects of environment
on this organization by stabilization or degeneration of
labile synapses associated with functioning. Learning, or
the acquisition of an associative property, is related to
a characteristic variability of the connective organization:
the interaction of the environment with the genetic program
is printed as a particular pattern of such organization through
neuronal functioning. An application of the theory to the
development of the neuromuscular junction is proposed and
the basic selective aspect of learning emphasized. |
A
Danchin, JP Changeux
Apprendre par stabilisation sélective de synapses en développement
In: "L'Unité de l'Homme" (Centre Royaumont
pour une Science de l'Homme) Le Seuil (1974): 320-350
A.
Danchin
À propos des poèmes à la manière T'ang
La traduction en jeu
Change (1974) 19: 149-155
A
Danchin
L'inné et l'acquis:
une théorie sélective de l'apprentissage
La Recherche (1974) 5: 184-187 (repris dans
des ouvrages généraux, traduit en espagnol et
en italien)
P
Courrège, A Danchin
Apprentissage et changement dans le système nerveux central
Colloque de Cerisy-la-Salle, Change (ed. 10/18) (1975): pp 60-73
JP Changeux, A Danchin
Selective stabilisation of developing synapses as a mechanism for the specification
of neuronal networks
Nature (1976) 264: 705-712 
JP Changeux, A Danchin
Biochemical models for the selective stabilisation of developing synapses
SES Symposium Book (WL Nastuk and GA Cottrell, eds.)(1977)
A
Danchin
Stabilisation fonctionnelle et épigenèse: une approche
biologique de la genèse de l'identité individuelle
In: "L'Identité" (JM Benoist, ed) Grasset (1977):
185-221 
A
Danchin
Spécification épigénétique des réseaux nerveux
par stabilisation fonctionnelle de synapses en développement
In: "Neurobiologie de l'Apprentissage" (R Delacour, ed)
Masson (1978): 198-209
A
Danchin
Comment peut-on parler de l'automate cérébral aujourd'hui
?
Revue Philosophique (1980) 3: 287-304
This research programme was set up in
1974 but never implemented. Several working papers in
particular by Tom Pitcairn and Scott Atran were written as a
preliminary set up of the programme. This situation led me to
shift my research programme to a completely new domain, microbial
genetics instead of neurobiology. A sequel of the programme was
the Chomsky-Piaget meeting organized at the Abbaye de Royaumont
in 1975
Extensive use of symbolic language in a crative fashion is specific
to Homo sapiens. The concept of communication, however, is a
pervasive one, manifesting itself in an extensive variety of
ways, from chemical markers among insects to bird songs, from
animal signalling to human languages to the sophisticated sharing
of cultural inheritance in literate societies.
The quest for the biological basis of language and communication
and the search for the possibility of a common root of thes related
phenomena in a fundamental anthropology implies a thorough analysis
of the most recent findings in the neurosciences and a fresh
review of some of the basic mechanisms of evolution. The solid
framework of physiology and of the dynamics of evolution lends
itself to a re-definition of certain traits in order to account
for behavioral adaptation, learning abilities, and symbolic modes
of communication. The understanding of the development of structures
allowing for the constitution of a great variety of messages
based on a combination of discrete units which are in themselves
value-free is a major theoretical challenge.
The present somewhat primitive state of investigations in these
fields is partly due to the fact that a solid experimental praxis
has been developed for animals only, leaving out the most complex
and fascinating repository of these phenomena: the human species.
On the other hand, anthropology, sociolinguistics and psychology
have developed autonomous logics of investigation whose direct
application to anatomicla and physiological data is very difficult
if not impossible.
Without denying the autonomy of these levels of description
and without pretending to reduce linguistics and psychology to
neuronal circuitry, a new intermediate level of analysis seems
nevertheless to be attainable through a cautious but imaginative
cross-confrontation of models, theories, data and techniques.
The initial aim of this project — and the first problem to overcome
— is to bring together the enormous and often redundant wealth
of data on physiology, anatomy, evolution and behavior of non-human
species, and to confront them with the symmetrical but independent
theories and experiments in the psycholinguistic disciplines.
As a consequence of these critical confrontations, lines of
convergence and divergence will emerge more clearly, hopefully
permitting a re-phrasing of the fundamental problems. Once this
necessary and comprehensive analysis is acieved, and new investigative
strategies and methodologies worked out, lines of development
for tuture resarch will be charted and suitable model systems
chosen accordingly.
A complementary study of animal and human communication provides
a particularly auspicious opportunity for bringing the life sciences
and the human sciences into a common focus on an anthropological
problem whose biological basis is still at the early stage of
exploration.
Five major lines of enquiry are presently envisaged:
a) A study of the development and the structural
organization of communication networks along the phylogenetic
tree, with special emphasis on the genetic aspects of the problem. The analysis
of genetic dterminations on the communication patterns of the
various species and the selective pressures that these latter
exert on the species' genome can yield new ways of examining
adatation and group organization in living systems.
b) The mechanisms of learning and their
genetic envelope. Song-learning
in birds, and the transmission of acquired skills as a phenomenon
of individual-to-individual communication. Learning and communication
abilities. Learning and contingent events.
c) The biology of human language with special
emphasis on the logic of inference to man of experimental evidence
regrading animals. A survey of neuropsychological data (aphasia, alexia,
split brain surgery). Voice versus writing, words versus songs,
and the role of rhythms on memory and learning in man.
d) Epistemology of communication systems. Need to
clarify the distinction between human language on the one hand
and communication systems in general on the other hand, from
the point of view of the science of knowldedge ("Is the genetic
code a language?" – "Is the bee communication system a language?").
The problem of levels of analysis. Context and meaning as categories
of linguistic analysis. The debate on semantics and the possibility
of a non-semantic approach to linguistics. Independence and
inter-dependence of the different levels of analysis (phonological,
semantical, syntactical, generative, structural, historical,
evolutionary, etc.).
e) Socialization of language and infant-caretaker relationship.
Language pedagogy in man, and learning through observation in
animals. Comparative study of social dynamics of communication
in different societies. The role of random events and of internal
constraints in communication systems. The ontogeny of communication.
f) Arts, aesthetics and super-symbolic
communication. The artistic
and poetic message as a communication device. Individual versus
collective modes of elaboration and interpretation of super-symbolic
messages.
As a preliminary step, a small team of rapporteurs will work
together for a period ranging from one to three months, eventually
paying visits to laboratories and individual scholars in the
disciplines involved.
Critical erports elaborated by this interdisciplinary team will
then be circulated and discussed at meetings in Europe and America
bringing together the original research team and changing groups
of senior researchers.
The object of these meetings will be to refine the findings
of the original team, to work these existing findings into form
for publication, and to lay out new lines of enquiry. In principle
such meetings would last two days and would convene 10 to 12
scholars chosen in large part by the members of the original
research team.
A possible composition of the original reasearch team would
be:
• One neurobiologist with some background in linguistics
and experimental psychology: Antoine Danchin, Institut Pasteur
de Paris
• One ethologist with some background in neurobiology:
Tom Pitcairn, Percha (Munich)
• One linguist oriented toward formal approaches:
François Dell, EHESS, Paris
• One linguist oriented toward psychological experimental
approaches: David Premack, University of California or a young
collaborator
• One linguist with special competence in semantic
problems: Jerry Katz, MIT, or a young collaborator
• One art critic with emphasis on communication theory:
Umberto Eco, Parma, or a young collaborator
Once again, the list of names is tentative and neither exhaustive
nor exclusive, designed rather to indicate the kind of specialists
we have in mind for the project.
A preliminary list of specialists to be consulted during the
planning phase, or who could take part in some capacity or other
in the three year project. Since then, several passed away:
- Seymour Papert, Department of Artificial Intelligence, MIT
- Jerry A. Fodor, Department of Psychology, MIT
- Colwyn
B. Trevarthen, Department of Psychology, University
of Edinburgh
- Julian de Ajuriaguerra (1911-1993), Clinique Psychiâtrique de l'Université
de Genève
- Vincent Bloch, Department of Psychophysiology, Université
des Sciences et Techniques, Lille
- E. Roy John (1924-2009), neurophysiologist, Brain Research Laboratories at the New York University School of Medicine
- Peter Marler, ethologist, Rockefeller University, New York
- Ursula Bellugi-Klima, psycholinguist, The Salk Institute
for Biological Studies
- Edward
S. Klima (1931-2008), linguist, The Salk Institute
for Biological Studies, San Diego
- Salvador E. Luria (1912-1991), Department of Biology, MIT
- Jacques
Mehler, psycholinguist, Université Paris VIII
- Heidelise
Rivinus, St. Mary's Hospital Medical School, London
- Jean-Pierre Changeux, Institut Pasteur de Paris
- Dan Sperber, Laboratoire d'Ethnologie, University of Paris
- Gilles Fauconnier, linguist, University of Paris
- John Derek Freeman (1916-2001), Department of Anthropology
and Sociology, Australian National University
- Bernhard
Hassenstein, Biologisches Institut, Albert-Ludwigs
Universität
- Hans
Kummer (1930-), Institute of Biology, University of
Zürich, Switzerland
- Christian Vogel (1933-1994), Department of Anthropology, Georg-August
Universität, Göttingen
- Klaus
Immelmann (1935-1987), Zoologisches Institut, T. U.
Carolo-Wilhemina, Braunschweig
- Paul Ekman, San Francisco, California
- N. Blurton-Jones, Insitute of Child Health, London
- Erving Goffman (1922-1982) Department of Anthropology, University of
Pennsylvania
- W.C. McGrew, Department of Psychology, University of
Edinburgh
- Valentino Braitenberg, Wenner-Gren Foundation for Anthropological
Research, New York
- Michael Argyle, Institute of Experimental Psychology, Oxford
- R.L. Birdwhistell, kinesics, University of Pennsylvania
- J. van Hooff, ethology and socio-ecology, Universiteit Utrecht,
Holland
- P.E. Meehl, Department of Psychology, University of Minnesota
Several texts were written in support of this programme, in
particulat texts by Tom Pitcairn and Scott Atran.
My own contribution was focused on The Biological Features of
the Problem (in French).

Not much has been left from that meeting,
where Hans-Lukas
Teuber participated. Let me quote Massimo
Piattelli-Palmarini:
« This brings me to two curious episodes, both
of which involve Jacques [Mehler].
The first happened at Endicott House, a sumptuous residence outside
Boston, given to MIT by a rich family of insurers. The Royaumont
center, in close collaboration with Chomsky and Luria, organized
a weekend-long informal workshop at Endicott House, to explore
this famous biological "envelope" of the mind. If
attendance by the senior component was impressive there and then
(Monod,Chomsky, Luria, Zella Hurwits, Hans-Lukas Teuber, Vassily
Leontieff, Daniel Bell, Michael Scriven, Daniel Lehrman, Edgar
Morin), attendance by the young was no less impressive in hindsight
(Jacques, Susan Carey, Ned Block, Peter and Jill de Villiers, Eric
Wanner, Paula Meniuk).
At one of the sessions, Jacques had just started presenting data
from psycholinguistics, including the celebrated archetypal garden-path
sentence "The horse raced past the barn fell." A question was
asked, and before Jacques could reply, Noam sprang up, went to
the blackboard, almost snatched the chalk from Jacques' hand
and answered the question at length. The time allotted to the
presentation by Jacques was almost entirely usurped by Noam and
by the intense discussion that ensued... » [Piattelli-Palmarini]
Massimo does not remember that I played my
role there. As a very young scientist, I was shocked to see the
way Jacques Mehler had been treated, and I also went to the board,
to try to contradict Noam Chomsky's rebuttal of the semantic
importance of language. I reminded him something that I had witnessed
not so long ago, when living in a small village of West Africa
(Lay, then Upper Volta, now Burkina Faso) in company with my
friend Hilaire Tiendrébéogo: children and young adults had the
habit, at evenings to convey and begin stories that were clearly
organised by rythm.
And this organisation of the sentences conveyed, in itself, a
particular level of communication, which could be easily caught
by ear (perhaps in particular when one had a limited understanding
of the language). And Chomsky snapped back at me with a "data
make no sense",
that I still vividly remember, and which has since then been
one of my mottos...
An account of the meeting was to be published,
and papers were collected. A major author would have been Teuber,
but, unfortunately he died in a swimming accident when on vacation,
before the book could be completely assembled.
« The second episode involves Piaget during
the preparation of the Royaumont debate with Chomsky. »
[Piattelli-Palmarini] Piaget was opposed
to the presence of Jacques Mehler at the meeting...
Based on a work developed within the exploration of the programme
"Human communication - Animal communication", Noam Chomsky and
Jean Piaget were invited by the CRSH to debate on the theme: "Language
and Learning" at
the Abbaye de Royaumont in october 1975.
On usage of the
term phenocopy
Massimo PIattelli-Palmarini
Language, brain, and cognitive development: essays in honor of
Jacques Mehler
This debate was paralleled by a reflection to organise further
studies in semiology, with Thomas Sebeok, Umberto Eco and others.
Kot Jeleński via his collaboration with François Bondy and others
asked me to participate to a meeting
of the Aspen Foundation in Berlin in 1975.
A
Danchin
Note critique sur l'emploi du terme
phénocopie
In: "Théories du langage, théories de l'apprentissage"
(CRSH)
Le Débat Chomsky-Piaget, Le Seuil (1979) pp 109-114 (traduit en anglais en
1981)
For some reason the contribution of my work has been perceived
in Italy as of some importance in the domain of philosophy. This
was certainly the result of the stance I took, derived from the
view I had constructed together with Jean-Pierre Changeux and
Philippe Courrège, of the human brain and its original properties.
Yet, rather than sticking to a mechanical view of learning and
memory, I progressively shifted to a view where information is
a central currency that has to be taken into account as an authentic
principle of Reality. This meant that brain had to be seen as
an information trap. But, at the difference of the cell, or for
that matter, the organism itself, the brain departs from the
standard features of Turing Machines. I perceive the human brain
as a Turing-Machine-in-becoming, progressively separating the
program from the machine, with language as the coded element
of the program.
The interest of italian thinkers for this type of reflection
led some to ask me to contribute to conferences and texts in
Italy. Ruggiero Romano, as a prominent historian of the western
thought, and supported by the Foundation Einaudi, decided to
undertake a grand intellectual entreprise, an general encyclopedy
of philosophy, Enciclopedia Einaudi. In parallel he discussed
with the political authorities of his birth place, Fermo — where
sit the fascinating library of Christine of Sweden — of the idea
to create on a regular basis an intellectual rendez-vous, on
a biennial basis. This was to become Fermo's Biennial Encounters,
that he asked me to organise with him.
The adventure resulted in two meetings only, because, supported
by the Foundation Einaudi, it could not find further support
when the Foundation became bankrupt. The Enciclopedia entreprise
(1977-1984) also collapsed and was never completed.
The first meeting, Il Tempo, was held in Fermo in 1980, with:
Ruggiero
Romano (1923-2002) ; Giuseppe
Papagno (1938-2009)
; Jean-Claude
Schmitt ; Fernando
Gil (1937-2006) ; Alberto
Asor Rosa ; Krzysztof
Pomian ; Jean
Petitot ; Giulio
Giorello ;
Antoine Danchin ; René
Thom (1923-2002) ; Marco
Mondadori (1945-1999) ; Arnaldo
Petterlini ; Eduardo
Prado Coelho (1944-2007) ; Umberto Eco
The text of the conference was published in Italian in 1981
by il Saggiatore, MIlano, under the title Le
frontiere del tempo
The second meeting, Il Sangue, Myti e Realtà, was held
in 1982. A meeting was planned for 1984, but had to be cancelled
as the consequence of Einaudi's bankrupt.

A
Danchin
I principi biologici della comunicazione
Enciclopedia della Scienza et della Technica (Annuaria 75 EST)
Mondadori (1975): 151-160
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