1967-1969 Nuclear Magnetic Resonance probing of transfer RNA structure; Institut de Biologie Physico-Chimique; Museum d'Histoire Naturelle
A
Danchin
Contribution à l'étude de l'acide ribonucléique
de transfert par la mesure du temps de relaxation longitudinal des protons
en présence d'un ion paramagnétique, en spectrométrie
de résonance magnétique nucléaire
Thèse de troisième cycle, 20 décembre 1967
M Grunberg-Manago, M Cohn, MN Thang, B Beltchev, A Danchin,
L Dimitrijevic
Influence of the structure of transfer RNA on its interaction with enzymes
and divalent cations
In: "Molecular Association in Biology", Academic Press,
New York (1968)
M Grunberg-Manago, M Cohn, MN Thang, B Beltchev, A Danchin,
L Dimitrijevic
Structure and function of transfer RNA
Universitets forlaget Oslo (1968): 113-141
M Cohn, A Danchin, M Grunberg-Manago
Proton magnetic relaxation studies of manganous
complexes of transfer RNA and related compounds
J Mol Biol (1969) 39: 199-217 
A Danchin
Binding of metal ions to macromolecules through
an NMR spectrometric method of investigation
J Theor Biol (1969) 25: 317-330
1970 Nuclear Magnetic Resonance probing of transfer RNA structure; Ecole Polytechnique
A Danchin, M Grunberg-Manago
Differences in binding of oligo C to charged and uncharged
tRNA
FEBS Lett (1970) 9: 327-330
A Danchin, M Guéron
Cooperative binding of manganese (II) to transfer
RNA
Eur J Biochem (1970) 16: 532-536
A Danchin, M Grunberg-Manago
Reversible inactivation of phenylalanine acceptor
activity of yeast tRNA-Phe by sodium borohydride
Biochem Biophys Res Commun (1970) 39: 683-690
A Danchin, M Guéron
Proton magnetic relaxation study of the manganese-transfer-RNA
complex
J Chem Phys (1970) 53: 3599-3609
 Dans
cet article nous montrons que le signal de relaxation du spin des
protons de l'eau induit par la présence de l'ion manganèse,
paramagnétique, et qui était jusqu'alors attribué au
mouvement local de la molécule complexant l'ion, est en fait
dû au spin électronique du manganèse, à la
température ordinaire. Cette observation fit
tomber en désuétude l'usage du manganèse pour
explorer la dynamique locale des macromolécules, car elle
révoquait en doute toutes les interprétations des recherches
précédemment menées dans le domaine |
 In
this paper we show that that the relaxation signal of the water molecule
protons, induced by the presence of the paramagnetic manganese ion,
which had until then been assigned to the local movements of the
molecule complexing the ion, is in fact due to the electronic spin
of manganese, at least at room temperature. This observation stopped
all use of the manganese ion as a tool to explore the local dynamics
of macromolecules, as it showed that the interpretation of all previous
research in the domain were wrong |
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1971 Organometallic chemistry: Exploration of covalent analogs of magnesium; École Polytechnique
A
Danchin
Structure tertiaire des ARN de transfert: sites des ions divalents par
résonance
magnétique. Propriétés biochimiques
Thèse de Doctorat ès Sciences Physiques, 22 mars 1971
A Danchin
A dynamic molecular model for transfer RNA
FEBS Lett (1971) 13: 152-156
A
Danchin
Marquage des acides nucléiques par des ions non
changeables. [Labelling of nucleic acids by
non exchangeable ions]
C R Acad Sci Hebd Seances Acad Sci D (1971) 273: 1636-1639
1972 Organometallic chemistry: Exploration of covalent analogs of magnesium; Institut de Biologie Physico-Chimique; Institut Pasteur de Paris
A Danchin, H Buc
Proton magnetic resonance studies on 5'- AMP site
in glycogen phosphorylase b
FEBS Lett (1972) 22: 289-293
A Danchin
Multiple states in macromolecules I. Qualitative
model for a single nucleation process
FEBS Lett (1972) 19: 293-296
A Danchin, MN Thang
Multiple states in macromolecules II. Entropic
behaviour of tRNA degraded by polynucleotide phosphorylase
FEBS Lett (1972) 19: 297-300
A Danchin
A new method for specific labelling of tRNA: preliminary
results on yeast tRNA-Phe
Biochimie (1972) 54: 333-337
A Danchin
tRNA structure and binding sites for cations
Biopolymers (1972) 11: 1317-1333
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1973 Learning and memory by selective stabilisation
of synapses
The serine effect and coordinate gene expression in bacteria
Organometallic chemistry: covalent analogs of magnesium; Institut de Biologie
Physico-Chimique; Institut Pasteur de Paris
RH Buckingham, A Danchin
Fluorescence of tryptophanyl-tRNA(Trp) from E.
coli; An interaction between the indole and tRNA and its dependence
on tRNA conformation
FEBS Lett (1973) 30: 236-238
RH Buckingham, A Danchin, M Grunberg-Manago
The effect of an intramolecular cross-link on
reversible denaturation in tryptophan transfer ribonucleic acid from Escherichia
coli
Biochemistry (1973) 12: 5393-5399
JP Changeux, P Courrège,
A Danchin
A theory of the epigenesis of neuronal networks
by selective stabilization of synapses
Proc Natl Acad Sci U S A (1973) 70: 2974-2978 
| Abstract: A formalism is introduced to represent the connective organization of an evolving neuronal network and the effects of environment on this organization by stabilization or degeneration of labile synapses associated with functioning. Learning, or the acquisition of an associative property, is related to a characteristic variability of the connective organization: the interaction of the environment with the genetic program is printed as a particular pattern of such organization through neuronal functioning. An application of the theory to the development of the neuromuscular junction is proposed and the basic selective aspect of learning emphasized. |
A Danchin
Does formylation of initiator tRNA act as a regulatory
signal in E. coli?
FEBS Lett (1973) 34: 327-332 
A Danchin, H Buc
Affinity labeling of the adenosine 5'-monophosphate
binding site of rabbit muscle glycogen phosphorylase b with an adenosine
5'-monophosphate-cobalt(3) complex
J Biol Chem (1973) 248: 3241-3247
| Abstract: A new affinity labeling method, based on organometallic chemistry, is presented which may be used for enzyme-catalyzing reactions in the presence of magnesium. This method uses the substrate-cobalt(III) analog of the substrate-magnesium complex as a covalent label of the active site. The specific case of rabbit muscle glycogen phosphorylase b, which has been covalently labeled with a AMP-Co(III) derivative at the allosteric site, is discussed. The stoichiometry and the extinction coefficient of the label have been determined. The association of this cobaltic complex to the enzyme is stable. The label destroys the activity on the subunit where it is bound; it slightly affects the binding of orthophosphate and it changes the response to the glycogen substrate from a noncooperative pattern to a cooperative binding. This shows that the label has an effect on the quaternary structure of phosphorylase b. In addition to the covalent binding of the label to the allosteric site, it is shown that its association can be reversed at will, i.e. it can be removed by the addition of small molecules containing thiol groups. |
A Danchin
Biological macromolecules labelling with covalent
complexes of magnesium analogs. I. The cobaltic Co(III) ion
Biochimie (1973) 55: 17-27
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1974 Learning and memory by selective stabilisation of synapses; the serine effect and coordinate gene expression in bacteria; Exploration of covalent analogs of magnesium: Institut de Biologie Physico-Chimique; Institut Pasteur de Paris
RH Buckingham, A Danchin, M Grunberg-Manago
Denaturation of UGA suppressor tRNA-Trp from E.
coli
Biochem Biophys Res Commun (1974) 56: 1-8
A Oplatka, MM Werber, A Danchin
Specific interaction of cobaltic complexes with
myosin
FEBS Lett (1974) 47: 7-10
MM Werber, A Oplatka, A Danchin
Affinity labeling of rabbit muscle myosin with
a cobalt(III)-adenosine triphosphate complex
Biochemistry (1974) 13: 2683-2688
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1975 Learning and memory by selective stabilisation of synapses; The serine effect and coordinate gene expression in bacteria; Exploration of covalent analogs of magnesium: Institut de Biologie Physico-Chimique; Institut Pasteur de Paris
H Buc, M Morange, F Garcia Blanco, A Danchin
Covalent and non-covalent analogs of 5'AMP: their function in the activation
of glycogen phosphorylase b from rabbit muscle.
In: "Proceedings of FEBS meeting, Budapest", Keliti Ed.
Review of the Hungarian Academy of Science (1975) 32:
57-76
A Danchin
Labelling of biological macromolecules with covalent
analogs of Magnesium. II. - Features of the chromic Cr (III) ion
Biochimie (1975) 57: 875-880
| L'ion chromique
voit ses orbitales d remplies, chacune, par un électron. Cela a pour
conséquence de rendre l'octaèdre de coordination de l'ion stable (orbitales
anti-liantes) et conduit le chrome a occuper de façon irréversibles des
sites de liaison à des métaux comme le magnésium ou d'autres métaux de
transition. C'est ce qui explique que le chrome (III) soit utilisé pour
le tannage du cuir, et aussi qu'il soit un poison, et non l'un des métaux
de transition utilisés par la vie. |
The
chromic ion sees its d orbitals filled, each by one electron.
This has the effect of stabilizing the octahedral coordination
of the ion (anti-bonding orbital) and leads chromium to occupy
irreversibly the binding sites normally used by metals such as magnesium
or other transition metal ions. This explains why chromium (III)
is used for tanning leather, and also why it is a poison, not a transition
metal used by life as iron, cobalt or manganese. |
A
Danchin
Problèmes techniques de la résonance
magnétique nucléaire des acides nucléiques. [Technical
problems in the nuclear magnetic resonance of nucleic acids]
Biochimie (1975) 57: 445-452
1976 Learning and memory by selective stabilisation of synapses, neuronal networks; The serine effect and coordinate gene expression in bacteria: Institut de Biologie Physico-Chimique
JP Changeux, A Danchin
Selective stabilisation of developing synapses
as a mechanism for the specification of neuronal networks
Nature (1976) 264: 705-712
A Danchin
A selective theory for the epigenetic specification
of the monospecific antibody production in single cell lines
Ann Immunol (Paris) (1976) 127: 787-804
HU Petersen, A Danchin, M Grunberg-Manago
Toward an understanding of the formylation of
initiator tRNA methionine in prokaryotic protein synthesis. I. In vitro studies
of the 30S and 70S ribosomal-tRNA complex
Biochemistry (1976) 15: 1357-1362
| Abstract: Formation of the 30S-tRNA initiation complex of Escherichia coli with nonformylated initiator tRNA is stimulated by all three initiation factors and is messenger dependent, whereas the complex formation involving the 70S ribosomes is strongly inhibited by initiation factors when the nonformylated species is used. When the 30S-Met-tRNAfMet complex is first formed and the 50S ribosomal subunit added subsequently, there is no significant inhibition by initiation factors and the nonformylated initiator tRNA is puromycin reactive. This leads to the conclusion that the formylation of the methionyl initator tRNA is only obligatory when polypeptide synthesis is initiated by nondissociated 70S ribosomes. |
HU Petersen, A Danchin, M Grunberg-Manago
Toward an understanding of the formylation of
initiator tRNA methionine in prokaryotic protein synthesis. II. A two-state
model for the 70S ribosome
Biochemistry (1976) 15: 1362-1369
| Abstract: The 70S ribosomes can select the proper initiator tRNA between Met-tRNAfMet and fMet-tRNAfMet. Experiments on binding and on formation of aminoacylpuromycin, as a function of magnesium, potassium, or initiation factors, suggest a two-state equilibrium for 70S particles, involving a minor, active conformation and a major one which is not readily active. The formyl group would act as a specific trigger to select the active conformation. Experimental results are interpreted following this simple model and equilibrium parameters, together with kinetic constants of the peptidyltransferase activity, are presented. |
M Uzan, A Danchin
A rapid test for the relA mutation in E.
coli
Biochem Biophys Res Commun (1976) 69: 751-758
| Cet
article met en évidence pour la première fois que l'"effet
sérine" découvert indépendamment par Alföldi
n'est pas contrecarré par la thréonine ou le 2-cétobutyrate,
mais est la manifestation d'une sensibilité particulière
des bactéries à la sérine, pour une raison que
nous venons de comprendre (6 janvier 2006) |
|
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1977 The serine effect and coordinate gene expression in bacteria; Neuronal networks: Institut de Biologie Physico-Chimique
A Danchin
A new technique for selection of sensitive and
auxotrophic mutants of E. coli: isolation of a strain sensitive to
an excess of one-carbon metabolites
Mol Gen Genet (1977) 150: 293-299
MM Werber, A Danchin
Labeling and inhibition of myosin by 'in situ-oxidized'
and presynthesized Co(III) complexes
FEBS Lett (1977) 73: 105-108
MM Werber, A Danchin
Inert Co(III) complexes as reagents for nucleotide
binding sites
Methods Enzymol (1977) 46: 312-321
MM Werber, A Danchin, Y Hochman, C Carmeli, A Lanir
Co(III)-ATP complexes as affinity labelling reagents of myosin and coupling
factor-1 ATPases.
In: "Metal ligand interactions in Organic Chemistry and Biochemistry"
(B Pulman, N Goldblum, eds.), Reidel Publishing Comp any Dordrecht, Holland
ed. 9 (1977): pp 283-290
JP Changeux, A Danchin
Biochemical models for the selective stabilisation of developing synapses
SES Symposium Book (WL Nastuk and GA Cottrell, eds.)(1977)
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1978 Coordinate gene expression in bacteria: Institut de Biologie Physico-Chimique
J Granot, MM Werber, A Danchin
Structural and exchange properties of "Co(III)-phenanthroline-ATP":
a labeling reagent for the active site of ATPases
Bioinorg Chem (1978) 9: 81-92
E Joseph, A Danchin, A Ullmann
Modulation of the lactose operon mRNA turnover
by inhibitors of dihydrofolate reductase
Biochem Biophys Res Commun (1978) 84: 769-776
HU Petersen, E Joseph, A Ullmann,
A Danchin
Formylation of initiator tRNA-methionine in procaryotic
protein synthesis: in vivo polarity in lactose operon expression
J Bacteriol (1978) 135: 453-459 
M Uzan, A Danchin
Correlation between the serine sensitivity and the derepressibility of the ilv genes
in Escherichia coli relA- mutants
Mol Gen Genet (1978) 165: 21-30
A
Danchin
Spécification épigénétique des réseaux
nerveux par stabilisation fonctionnelle de synapses en développement
In: "Neurobiologie de l'Apprentissage" (R Delacour, ed)
Masson (1978): 198-209
A
Danchin
Ordre et Dynamique du Vivant. Chemins de la Biologie Moléculaire
Le Seuil (1978) 350 p
A
Danchin
Entropie et Ordre Biologique
La Recherche (1978) 92: 788-791
| The
second law of thermodynamics does not necessarily imply an increase
in disorder. |
|
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1979 Coordinate gene expression in bacteria: one carbon metabolism, cyclic AMP and its receptor: Institut de Biologie Physico-Chimique
A Danchin, L Dondon
Regulatory features of tRNALeu I expression in Escherichia
coli K12
Biochem Biophys Res Commun (1979) 90: 1280-1286
A Danchin
The specification of the immune response: a general
selective model
Mol Immunol (1979) 16: 515-526
A Danchin
Is a metabolic control for the doubling of the
macromolecule synthesizing machinery possible?
Biochimie (1979) 61: 45-50
J Daniel, A Danchin
Involvement of cyclic AMP and its receptor protein
in the sensitivity of Escherichia coli K 12 toward serine: excretion
of 2-ketobutyrate, a precursor of isoleucine
Mol Gen Genet (1979) 176: 343-350
A Spassky, SJ Busby, A Danchin,
H Buc
On the binding of tRNA to Escherichia coli RNA polymerase
Eur J Biochem (1979) 99: 187-201
A Ullmann, E Joseph, A Danchin
Cyclic AMP as a modulator of polarity in polycistronic
transcriptional units
Proc Natl Acad Sci U S A (1979) 76: 3194-3197
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1980
A Danchin, L Dondon
Serine sensitivity of Escherichia coli K
12: partial characterization of a serine resistnat mutant that is extremely
sensitive to 2-ketobutyrate
Mol Gen Genet (1980) 178: 155-164
A Danchin, A Ullmann
The coordinate expression of polycistronic operons
in bacteria
Trends in Biochem Sci (1980) 5: 51-52
C Guidi-Rontani, A Danchin, A Ullmann
Catabolite repression in Escherichia coli mutants
lacking cyclic AMP receptor protein
Proc Natl Acad Sci U S A (1980) 77: 5799-5801
A Ullmann, A Danchin
Role of cyclic AMP in regulatory mechanisms in
bacteria
Trends in Biochem Sci (1980) 5: 95-96
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JP
Changeux, P Courrège, A Danchin, JM Lasry
Un mécanisme biochimique pour l'épigenèse
de la jonction neuro-musculaire
C R Séances Acad Sci III (1981) 292: 449-453
A Danchin, L Dondon, E Joseph,
A Ullmann
Transcription-translation coupling and polarity:
a possible role of cyclic AMP
Biochimie (1981) 63: 419-424
A Danchin, PP Slonimski
Generation of immune specificity: a working hypothesis
Biosystems (1981) 13: 259-266
J Daniel, E Joseph, A Ullmann,
A Danchin
crpX mutants of Escherichia coli K12:
selection and physiological properties
FEMS Microbiol Lett (1981) 10: 389-393
C Guidi-Rontani, A Danchin, A Ullmann
Isolation and characterization of an Escherichia
coli mutant affected in the regulation of adenylate cyclase
J Bacteriol (1981) 148: 753-761
E Joseph, A Danchin, A Ullmann
Regulation of galactose operon expression: glucose
effects and role of cyclic adenosine 3',5'-monophosphate
J Bacteriol (1981) 146: 149-154
A Roy, A Danchin
Restriction map of the cya region of
the Escherichia coli K12 chromosome
Biochimie (1981) 63: 719-722
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A Danchin
From mitochondria to nuclei: regulation of split
genes expression
Prog Clin Biol Res (1982) 102 Pt B: 375-396
A Danchin
The specification of the immune response revisited
Surv Immunol Res (1982) 1: 173-183
C Guidi-Rontani, A Danchin, A Ullmann
Pleiotropic expression of catabolic operons in
the absence of the cAMP-CAP complex: the case of the maltose regulon
Ann Microbiol (Paris) (1982) 133A: 81-85
A Roy, A Danchin
The cya locus of Escherichia coli K12:
organization and gene products
Mol Gen Genet (1982) 188: 465-471
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R Bitoun, H De Reuse, D Touati-Schwartz,
A Danchin
The phosphoenol pyruvate dependent carbohydrate
phosphotransferase system of Escherichia coli K 12: cloning of the ptsHI-crr region
and studies with a pts-lac operon fusion
FEMS Microbiology Letters (1983) 16: 163-167
J Couderc, Y Perrodon, M Ventura,
P Liacopoulos, A Danchin
Specification of the immune response: its suppression
induced by chloramphenicol in vitro
Biosci Rep (1983) 3: 19-29
J Daniel, L Dondon, A Danchin
2-Ketobutyrate: a putative alarmone of Escherichia
coli
Mol Gen Genet (1983) 190: 452-458
P Leplatois, A Danchin
Vectors for high conditional expression of cloned
genes
Biochimie (1983) 65: 317-324
A Roy, A Danchin, E Joseph, A Ullmann
Two functional domains in adenylate cyclase of Escherichia
coli
J Mol Biol (1983) 165: 197-202
A Roy, C Haziza, A Danchin
Regulation of adenylate cyclase synthesis in Escherichia
coli: nucleotide sequence of the control region
EMBO J (1983) 2: 791-797
F
Traincard, T Ternynck, A Danchin, S Avrameas
Une technique immunoenzymatique pour la mise en évidence
de l'hybridation moléculaire entre acides nucléiques. [An
immunoenzyme technique for demonstrating the molecular hybridization of nucleic
acids]
Ann Immunol (Paris) (1983) 134D: 399-404
A Ullmann, A Danchin
Role of cyclic AMP in bacteria
Adv Cyc Nucleot Res (1983) 15: 1-53
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H Aiba, K Mori, M Tanaka, T Ooi,
A Roy, A Danchin
The complete nucleotide sequence of the adenylate
cyclase gene of Escherichia coli
Nucleic Acids Res (1984) 12: 9427-9440
A Danchin, N Guiso, A Roy, A Ullmann
Identification of the Escherichia coli cya gene
product as authentic adenylate cyclase
J Mol Biol (1984) 175: 403-408
A Danchin, L Dondon, J Daniel
Metabolic alterations mediated by 2-ketobutyrate
in Escherichia coli K12
Mol Gen Genet (1984) 193: 473-478
J Daniel, E Joseph, A Danchin
Role of 2-ketobutyrate as an alarmone in E.
coli K12: inhibition of adenylate cyclase activity mediated by the phosphoenolpyruvate:
glucose phosphotransferase transport system
Mol Gen Genet (1984) 193: 467-472
H De Reuse, E Huttner, A Danchin
Analysis of the ptsH-ptsI-crr region in Escherichia coli K-12:
evidence for the existence of a single transcriptional unit
Gene (1984) 32: 31-40
C Guidi-Rontani, A Danchin, A Ullmann
Transcriptional control of polarity in Escherichia
coli by cAMP
Mol Gen Genet (1984) 195: 96-100
N Guiso, M Dreyfus, O Siffert,
A Danchin, A Spyridakis, A Gargouri, M Claisse, PP Slonimski
Antibodies against synthetic oligopeptides allow
identification of the mRNA-maturase encoded by the second intron of the yeast
cob-box gene
EMBO J (1984) 3: 1769-1772
C Jacq, J Banroques, AM Becam,
PP Slonimski, N Guiso, A Danchin
Antibodies against a fused 'lacZ-yeast mitochondrial
intron' gene product allow identification of the mRNA maturase encoded by
the fourth intron of the yeast cob-box gene
EMBO J (1984) 3: 1567-1572
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A Danchin, PP Slonimski
Split genes
Endeavour (1985) 9: 18-27
H De Reuse, A Roy, A Danchin
Analysis of the ptsH-ptsI-crr region
in Escherichia coli K-12: nucleotide sequence of the ptsH gene
Gene (1985) 35: 199-207
L Hedegaard, A Danchin
The cya gene region of Erwinia chrysanthemi B374:
organisation and gene products
Mol Gen Genet (1985) 201: 38-42
A Danchin, A Ullmann
Cyclic AMP in bacteria: catabolic repression and related processes
In: "Gene Manipulation and Expression", (Spivek and Glass
eds.) Croom HelM (1985): 255-272
A
Danchin
Contrôles métaboliques hiérarchisés chez les bactéries
In: Production d'agents thérapeutiques par génie génétique
(Ed. A Joyeaux, G Leygue, M Morre, R Roncucci, PH Schmelck) Sanofi Recherche
et Medsi/Gower (1985) pp 37-43
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