PLAN DU SITE PHILOSOPHIE HISTORY OF BIOLOGY PHILOSOPHY SITE MAP



1967-1971 IBPC-1981 REG-1986 REG-1991 REG-1996 GGB-2001 GGB-2006 AMA-2011 AMA-2016
1972-1974 IBPC-1982 REG-1987 REG-1992 REG-1997 GGB-2002 GGB-2007 AMA-2012 ICAN-2017 
1975-1978 BRC-1983 REG-1988 REG-1993 REG-1998 GGB-2003 GGB-2008 AMA-2013 ICAN-2018
IBPC-1979 BRC-1984 REG-1989 REG-1994 REG-1999 GGB-2004 AMA-2009 AMA-2014 Cochin-2019
IBPC-1980 BRC-1985 REG-1990 REG-1995 GGB-2000 GGB-2005 AMA-2010 AMA-2015  

Peer-reviewed publications are indicated in red

Publications in the domain of Philosophy, History of Sciences and Ethics

Popularisation

Symplectic Biology

Lectures and seminars


1967-1969 Nuclear Magnetic Resonance probing of transfer RNA structure (Institut de Biologie Physico-Chimique; Museum d'Histoire Naturelle)

fr A Danchin
Contribution à l'étude de l'acide ribonucléique de transfert par la mesure du temps de relaxation longitudinal des protons en présence d'un ion paramagnétique, en spectrométrie de résonance magnétique nucléaire
Thèse de troisième cycle, 20 décembre 1967

M Grunberg-Manago, M Cohn, MN Thang, B Beltchev, A Danchin, L Dimitrijevic
Influence of the structure of transfer RNA on its interaction with enzymes and divalent cations
In: "Molecular Association in Biology", Academic Press, New York (1968)

M Grunberg-Manago, M Cohn, MN Thang, B Beltchev, A Danchin, L Dimitrijevic
Structure and function of transfer RNA
Universitets forlaget Oslo (1968): 113-141

M Cohn, A Danchin, M Grunberg-Manago
Proton magnetic relaxation studies of manganous complexes of transfer RNA and related compounds
J Mol Biol (1969) 39: 199-217 pubmed

A Danchin
Binding of metal ions to macromolecules through an NMR spectrometric method of investigation
J Theor Biol (1969) 25: 317-330 pubmed

1970 Nuclear Magnetic Resonance probing of transfer RNA structure (Ecole Polytechnique)

A Danchin, M Grunberg-Manago
Differences in binding of oligo C to charged and uncharged tRNA
FEBS Lett (1970) 9: 327-330 pubmed

A Danchin, M Guéron
Cooperative binding of manganese (II) to transfer RNA
Eur J Biochem (1970) 16: 532-536 pubmed

A Danchin, M Grunberg-Manago
Reversible inactivation of phenylalanine acceptor activity of yeast tRNA-Phe by sodium borohydride
Biochem Biophys Res Commun (1970) 39: 683-690 pubmed

A Danchin, M Guéron
Proton magnetic relaxation study of the manganese-transfer-RNA complex
J Chem Phys (1970) 53: 3599-3609 pubmed

frDans cet article nous montrons que le signal de relaxation du spin des protons de l'eau induit par la présence de l'ion manganèse, paramagnétique, et qui était jusqu'alors attribué au mouvement local de la molécule complexant l'ion, est en fait dû au spin électronique du manganèse, à la température ordinaire. Cette observation fit tomber en désuétude l'usage du manganèse pour explorer la dynamique locale des macromolécules, car elle révoquait en doute toutes les interprétations des recherches précédemment menées dans le domaine   ukIn this paper we show that that the relaxation signal of the water molecule protons, induced by the presence of the paramagnetic manganese ion, which had until then been assigned to the local movements of the molecule complexing the ion, is in fact due to the electronic spin of manganese, at least at room temperature. This observation stopped all use of the manganese ion as a tool to explore the local dynamics of macromolecules, as it showed that the interpretation of all previous research in the domain were wrong

 

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1971 Organometallic chemistry: Exploration of covalent analogs of magnesium (École Polytechnique)

fr A Danchin
Structure tertiaire des ARN de transfert: sites des ions divalents par résonance magnétique. Propriétés biochimiques
Thèse de Doctorat ès Sciences Physiques, 22 mars 1971

A Danchin
A dynamic molecular model for transfer RNA
FEBS Lett (1971) 13: 152-156 pubmed

fr A Danchin
Marquage des acides nucléiques par des ions non changeables. [Labelling of nucleic acids by non exchangeable ions]
C R Acad Sci Hebd Seances Acad Sci D (1971) 273: 1636-1639 pubmed


1972 Organometallic chemistry: Exploration of covalent analogs of magnesium (Institut de Biologie Physico-Chimique; Institut Pasteur)

A Danchin, H Buc
Proton magnetic resonance studies on 5'- AMP site in glycogen phosphorylase b
FEBS Lett (1972) 22: 289-293 pubmed

A Danchin
Multiple states in macromolecules I. Qualitative model for a single nucleation process
FEBS Lett (1972) 19: 293-296 pubmed

A Danchin, MN Thang
Multiple states in macromolecules II. Entropic behaviour of tRNA degraded by polynucleotide phosphorylase
FEBS Lett (1972) 19: 297-300 pubmed

A Danchin
A new method for specific labelling of tRNA: preliminary results on yeast tRNA-Phe
Biochimie (1972) 54: 333-337 pubmed

A Danchin
tRNA structure and binding sites for cations
Biopolymers (1972) 11: 1317-1333 pubmed

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1973-1976 Epigenesis: learning and memory by selective stabilisation of synapses
The serine effect and coordinate gene expression in bacteria
Organometallic chemistry: covalent analogs of magnesium (Institut de Biologie Physico-Chimique; Institut Pasteur)

RH Buckingham, A Danchin
Fluorescence of tryptophanyl-tRNA(Trp) from E. coli; An interaction between the indole and tRNA and its dependence on tRNA conformation
FEBS Lett (1973) 30: 236-238 pubmed

RH Buckingham, A Danchin, M Grunberg-Manago
The effect of an intramolecular cross-link on reversible denaturation in tryptophan transfer ribonucleic acid from Escherichia coli
Biochemistry (1973) 12: 5393-5399 pubmed


JP Changeux, P Courrège, A Danchin
A theory of the epigenesis of neuronal networks by selective stabilization of synapses
Proc Natl Acad Sci U S A (1973) 70: 2974-2978 pubmed pnas
Abstract: A formalism is introduced to represent the connective organization of an evolving neuronal network and the effects of environment on this organization by stabilization or degeneration of labile synapses associated with functioning. Learning, or the acquisition of an associative property, is related to a characteristic variability of the connective organization: the interaction of the environment with the genetic program is printed as a particular pattern of such organization through neuronal functioning. An application of the theory to the development of the neuromuscular junction is proposed and the basic selective aspect of learning emphasized.

A Danchin
Does formylation of initiator tRNA act as a regulatory signal in E. coli?
FEBS Lett (1973) 34: 327-332 pubmed   pdf_file

A Danchin, H Buc
Affinity labeling of the adenosine 5'-monophosphate binding site of rabbit muscle glycogen phosphorylase b with an adenosine 5'-monophosphate-cobalt(3) complex
J Biol Chem (1973) 248: 3241-3247 pubmed pdf_file

Abstract: A new affinity labeling method, based on organometallic chemistry, is presented which may be used for enzyme-catalyzing reactions in the presence of magnesium. This method uses the substrate-cobalt(III) analog of the substrate-magnesium complex as a covalent label of the active site. The specific case of rabbit muscle glycogen phosphorylase b, which has been covalently labeled with a AMP-Co(III) derivative at the allosteric site, is discussed. The stoichiometry and the extinction coefficient of the label have been determined. The association of this cobaltic complex to the enzyme is stable. The label destroys the activity on the subunit where it is bound; it slightly affects the binding of orthophosphate and it changes the response to the glycogen substrate from a noncooperative pattern to a cooperative binding. This shows that the label has an effect on the quaternary structure of phosphorylase b. In addition to the covalent binding of the label to the allosteric site, it is shown that its association can be reversed at will, i.e. it can be removed by the addition of small molecules containing thiol groups.

A Danchin
Biological macromolecules labelling with covalent complexes of magnesium analogs. I. The cobaltic Co(III) ion
Biochimie (1973) 55: 17-27 pubmed

RH Buckingham, A Danchin, M Grunberg-Manago
Denaturation of UGA suppressor tRNA-Trp from E. coli
Biochem Biophys Res Commun (1974) 56: 1-8 pubmed

A Oplatka, MM Werber, A Danchin
Specific interaction of cobaltic complexes with myosin
FEBS Lett (1974) 47: 7-10 pubmed

MM Werber, A Oplatka, A Danchin
Affinity labeling of rabbit muscle myosin with a cobalt(III)-adenosine triphosphate complex
Biochemistry (1974) 13: 2683-2688 pubmed

H Buc, M Morange, F Garcia Blanco, A Danchin
Covalent and non-covalent analogs of 5'AMP: their function in the activation of glycogen phosphorylase b from rabbit muscle.
In: "Proceedings of FEBS meeting, Budapest", Keliti Ed.
Review of the Hungarian Academy of Science (1975) 32: 57-76

A Danchin
Labelling of biological macromolecules with covalent analogs of Magnesium. II. - Features of the chromic Cr (III) ion
Biochimie (1975) 57: 875-880 pubmed

frL'ion chromique voit ses orbitales d remplies, chacune, par un électron. Cela a pour conséquence de rendre l'octaèdre de coordination de l'ion stable (orbitales anti-liantes) et conduit le chrome a occuper de façon irréversibles des sites de liaison à des métaux comme le magnésium ou d'autres métaux de transition. C'est ce qui explique que le chrome (III) soit utilisé pour le tannage du cuir, et aussi qu'il soit un poison, et non l'un des métaux de transition utilisés par la vie.   ukThe chromic ion sees its d orbitals filled, each by one electron. This has the effect of stabilizing the octahedral coordination of the ion (anti-bonding orbital) and leads chromium to occupy irreversibly the binding sites normally used by metals such as magnesium or other transition metal ions. This explains why chromium (III) is used for tanning leather, and also why it is a poison, not a transition metal used by life as iron, cobalt or manganese.

fr A Danchin
Problèmes techniques de la résonance magnétique nucléaire des acides nucléiques. [Technical problems in the nuclear magnetic resonance of nucleic acids]
Biochimie (1975) 57: 445-452 pubmed

JP Changeux, A Danchin
Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks
Nature (1976) 264: 705-712 pubmed pdf

A Danchin
A selective theory for the epigenetic specification of the monospecific antibody production in single cell lines
Ann Immunol (Paris) (1976) 127: 787-804 pubmed

HU Petersen, A Danchin, M Grunberg-Manago
Toward an understanding of the formylation of initiator tRNA methionine in prokaryotic protein synthesis. I. In vitro studies of the 30S and 70S ribosomal-tRNA complex
Biochemistry (1976) 15: 1357-1362 pubmed pdf_file

Abstract: Formation of the 30S-tRNA initiation complex of Escherichia coli with nonformylated initiator tRNA is stimulated by all three initiation factors and is messenger dependent, whereas the complex formation involving the 70S ribosomes is strongly inhibited by initiation factors when the nonformylated species is used. When the 30S-Met-tRNAfMet complex is first formed and the 50S ribosomal subunit added subsequently, there is no significant inhibition by initiation factors and the nonformylated initiator tRNA is puromycin reactive. This leads to the conclusion that the formylation of the methionyl initator tRNA is only obligatory when polypeptide synthesis is initiated by nondissociated 70S ribosomes.

HU Petersen, A Danchin, M Grunberg-Manago
Toward an understanding of the formylation of initiator tRNA methionine in prokaryotic protein synthesis. II. A two-state model for the 70S ribosome
Biochemistry (1976) 15: 1362-1369 pubmed pdf

Abstract: The 70S ribosomes can select the proper initiator tRNA between Met-tRNAfMet and fMet-tRNAfMet. Experiments on binding and on formation of aminoacylpuromycin, as a function of magnesium, potassium, or initiation factors, suggest a two-state equilibrium for 70S particles, involving a minor, active conformation and a major one which is not readily active. The formyl group would act as a specific trigger to select the active conformation. Experimental results are interpreted following this simple model and equilibrium parameters, together with kinetic constants of the peptidyltransferase activity, are presented.

M Uzan, A Danchin
A rapid test for the relA mutation in E. coli
Biochem Biophys Res Commun (1976) 69: 751-758 pubmed

frCet article met en évidence pour la première fois que l'"effet sérine" découvert indépendamment par Alföldi n'est pas contrecarré par la thréonine ou le 2-cétobutyrate, mais est la manifestation d'une sensibilité particulière des bactéries à la sérine, pour une raison que nous venons de comprendre (6 janvier 2006)  

ukThis article shows for the first time that the "serine effect" independently discovered by Alföldi is not reversed by threonine or 2-ketobutyrate, but shows a particular sensitivity of bacteria towards serine, for a reason that we just understood (january 6th, 2006)

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1977 The serine effect and coordinate gene expression in bacteria; Neuronal networks: Institut de Biologie Physico-Chimique

A Danchin
A new technique for selection of sensitive and auxotrophic mutants of E. coli: isolation of a strain sensitive to an excess of one-carbon metabolites
Mol Gen Genet (1977) 150: 293-299 pubmed

MM Werber, A Danchin
Labeling and inhibition of myosin by 'in situ-oxidized' and presynthesized Co(III) complexes
FEBS Lett (1977) 73: 105-108 pubmed

MM Werber, A Danchin
Inert Co(III) complexes as reagents for nucleotide binding sites
Methods Enzymol (1977) 46: 312-321 pubmed

MM Werber, A Danchin, Y Hochman, C Carmeli, A Lanir
Co(III)-ATP complexes as affinity labelling reagents of myosin and coupling factor-1 ATPases.
In: "Metal ligand interactions in Organic Chemistry and Biochemistry" (B Pulman, N Goldblum, eds.), Reidel Publishing Comp any Dordrecht, Holland ed. 9 (1977): pp 283-290

JP Changeux, A Danchin
Biochemical models for the selective stabilisation of developing synapses
SES Symposium Book (WL Nastuk and GA Cottrell, eds.)(1977)

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1978 Coordinate gene expression in bacteria: Institut de Biologie Physico-Chimique

J Granot, MM Werber, A Danchin
Structural and exchange properties of "Co(III)-phenanthroline-ATP": a labeling reagent for the active site of ATPases
Bioinorg Chem (1978) 9: 81-92 pubmed

E Joseph, A Danchin, A Ullmann
Modulation of the lactose operon mRNA turnover by inhibitors of dihydrofolate reductase
Biochem Biophys Res Commun (1978) 84: 769-776 pubmed

HU Petersen, E Joseph, A Ullmann, A Danchin
Formylation of initiator tRNA-methionine in procaryotic protein synthesis: in vivo polarity in lactose operon expression
J Bacteriol (1978) 135: 453-459 pubmed J_Bact

M Uzan, A Danchin
Correlation between the serine sensitivity and the derepressibility of the ilv genes in Escherichia coli relA- mutants
Mol Gen Genet (1978) 165: 21-30 pubmed

fr A Danchin
Spécification épigénétique des réseaux nerveux par stabilisation fonctionnelle de synapses en développement
In: "Neurobiologie de l'Apprentissage" (R Delacour, ed) Masson (1978): 198-209

fr A Danchin
Ordre et Dynamique du Vivant. Chemins de la Biologie Moléculaire
Le Seuil (1978) 350 p

fr A Danchin
Entropie et Ordre Biologique
La Recherche (1978) 92: 788-791

ukThe second law of thermodynamics does not necessarily imply an increase in disorder.  

fr Le second principe de la thermodynamique n'implique pas une augmentation du désordre.

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1979 Coordinate gene expression in bacteria: one carbon metabolism, cyclic AMP and its receptor: Institut de Biologie Physico-Chimique

A Danchin, L Dondon
Regulatory features of tRNALeu I expression in Escherichia coli K12
Biochem Biophys Res Commun (1979) 90: 1280-1286 pubmed

A Danchin
The specification of the immune response: a general selective model
Mol Immunol (1979) 16: 515-526 pubmed

A Danchin
Is a metabolic control for the doubling of the macromolecule synthesizing machinery possible?
Biochimie (1979) 61: 45-50 pubmed

J Daniel, A Danchin
Involvement of cyclic AMP and its receptor protein in the sensitivity of Escherichia coli K 12 toward serine: excretion of 2-ketobutyrate, a precursor of isoleucine
Mol Gen Genet (1979) 176: 343-350 pubmed

A Spassky, SJ Busby, A Danchin, H Buc
On the binding of tRNA to Escherichia coli RNA polymerase
Eur J Biochem (1979) 99: 187-201 pubmed

A Ullmann, E Joseph, A Danchin
Cyclic AMP as a modulator of polarity in polycistronic transcriptional units
Proc Natl Acad Sci U S A (1979) 76: 3194-3197 pubmed

 

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1980

A Danchin, L Dondon
Serine sensitivity of Escherichia coli K 12: partial characterization of a serine resistnat mutant that is extremely sensitive to 2-ketobutyrate
Mol Gen Genet (1980) 178: 155-164 pubmed

A Danchin, A Ullmann
The coordinate expression of polycistronic operons in bacteria
Trends in Biochem Sci (1980) 5: 51-52 pubmed

C Guidi-Rontani, A Danchin, A Ullmann
Catabolite repression in Escherichia coli mutants lacking cyclic AMP receptor protein
Proc Natl Acad Sci U S A (1980) 77: 5799-5801 pubmed

A Ullmann, A Danchin
Role of cyclic AMP in regulatory mechanisms in bacteria
Trends in Biochem Sci (1980) 5: 95-96 pubmed

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1981

fr JP Changeux, P Courrège, A Danchin, JM Lasry
Un mécanisme biochimique pour l'épigenèse de la jonction neuro-musculaire
C R Séances Acad Sci III (1981) 292: 449-453 pubmed

A Danchin, L Dondon, E Joseph, A Ullmann
Transcription-translation coupling and polarity: a possible role of cyclic AMP
Biochimie (1981) 63: 419-424 pubmed

A Danchin, PP Slonimski
Generation of immune specificity: a working hypothesis
Biosystems (1981) 13: 259-266 pubmed

J Daniel, E Joseph, A Ullmann, A Danchin
crpX mutants of Escherichia coli K12: selection and physiological properties
FEMS Microbiol Lett (1981) 10: 389-393

C Guidi-Rontani, A Danchin, A Ullmann
Isolation and characterization of an Escherichia coli mutant affected in the regulation of adenylate cyclase
J Bacteriol (1981) 148: 753-761 pubmed

E Joseph, A Danchin, A Ullmann
Regulation of galactose operon expression: glucose effects and role of cyclic adenosine 3',5'-monophosphate
J Bacteriol (1981) 146: 149-154 pubmed

A Roy, A Danchin
Restriction map of the cya region of the Escherichia coli K12 chromosome
Biochimie (1981) 63: 719-722 pubmed

 

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1982

A Danchin
From mitochondria to nuclei: regulation of split genes expression
Prog Clin Biol Res (1982) 102 Pt B: 375-396 pubmed

A Danchin
The specification of the immune response revisited
Surv Immunol Res (1982) 1: 173-183 pubmed

C Guidi-Rontani, A Danchin, A Ullmann
Pleiotropic expression of catabolic operons in the absence of the cAMP-CAP complex: the case of the maltose regulon
Ann Microbiol (Paris) (1982) 133A: 81-85 pubmed

A Roy, A Danchin
The cya locus of Escherichia coli K12: organization and gene products
Mol Gen Genet (1982) 188: 465-471 pubmed

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1983

R Bitoun, H De Reuse, D Touati-Schwartz, A Danchin
The phosphoenol pyruvate dependent carbohydrate phosphotransferase system of Escherichia coli K 12: cloning of the ptsHI-crr region and studies with a pts-lac operon fusion
FEMS Microbiology Letters (1983) 16: 163-167

J Couderc, Y Perrodon, M Ventura, P Liacopoulos, A Danchin
Specification of the immune response: its suppression induced by chloramphenicol in vitro
Biosci Rep (1983) 3: 19-29 pubmed

J Daniel, L Dondon, A Danchin
2-Ketobutyrate: a putative alarmone of Escherichia coli
Mol Gen Genet (1983) 190: 452-458 pubmed

P Leplatois, A Danchin
Vectors for high conditional expression of cloned genes
Biochimie (1983) 65: 317-324 pubmed

A Roy, A Danchin, E Joseph, A Ullmann
Two functional domains in adenylate cyclase of Escherichia coli
J Mol Biol (1983) 165: 197-202 pubmed

A Roy, C Haziza, A Danchin
Regulation of adenylate cyclase synthesis in Escherichia coli: nucleotide sequence of the control region
EMBO J (1983) 2: 791-797 pubmed

fr F Traincard, T Ternynck, A Danchin, S Avrameas
Une technique immunoenzymatique pour la mise en évidence de l'hybridation moléculaire entre acides nucléiques. [An immunoenzyme technique for demonstrating the molecular hybridization of nucleic acids]
Ann Immunol (Paris) (1983) 134D: 399-404 pubmed

A Ullmann, A Danchin
Role of cyclic AMP in bacteria
Adv Cyc Nucleot Res (1983) 15: 1-53

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1984

H Aiba, K Mori, M Tanaka, T Ooi, A Roy, A Danchin
The complete nucleotide sequence of the adenylate cyclase gene of Escherichia coli
Nucleic Acids Res (1984) 12: 9427-9440 pubmed


A Danchin, N Guiso, A Roy, A Ullmann
Identification of the Escherichia coli cya gene product as authentic adenylate cyclase
J Mol Biol (1984) 175: 403-408 pubmed

A Danchin, L Dondon, J Daniel
Metabolic alterations mediated by 2-ketobutyrate in Escherichia coli K12
Mol Gen Genet (1984) 193: 473-478 pubmed

J Daniel, E Joseph, A Danchin
Role of 2-ketobutyrate as an alarmone in E. coli K12: inhibition of adenylate cyclase activity mediated by the phosphoenolpyruvate: glucose phosphotransferase transport system
Mol Gen Genet (1984) 193: 467-472 pubmed

H De Reuse, E Huttner, A Danchin
Analysis of the ptsH-ptsI-crr region in Escherichia coli K-12: evidence for the existence of a single transcriptional unit
Gene (1984) 32: 31-40 pubmed

C Guidi-Rontani, A Danchin, A Ullmann
Transcriptional control of polarity in Escherichia coli by cAMP
Mol Gen Genet (1984) 195: 96-100 pubmed

N Guiso, M Dreyfus, O Siffert, A Danchin, A Spyridakis, A Gargouri, M Claisse, PP Slonimski
Antibodies against synthetic oligopeptides allow identification of the mRNA-maturase encoded by the second intron of the yeast cob-box gene
EMBO J (1984) 3: 1769-1772 pubmed

C Jacq, J Banroques, AM Becam, PP Slonimski, N Guiso, A Danchin
Antibodies against a fused 'lacZ-yeast mitochondrial intron' gene product allow identification of the mRNA maturase encoded by the fourth intron of the yeast cob-box gene
EMBO J (1984) 3: 1567-1572 pubmed

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1985

A Danchin, PP Slonimski
Split genes
Endeavour (1985) 9: 18-27

H De Reuse, A Roy, A Danchin
Analysis of the ptsH-ptsI-crr region in Escherichia coli K-12: nucleotide sequence of the ptsH gene
Gene (1985) 35: 199-207 pubmed

L Hedegaard, A Danchin
The cya gene region of Erwinia chrysanthemi B374: organisation and gene products
Mol Gen Genet (1985) 201: 38-42

A Danchin, A Ullmann
Cyclic AMP in bacteria: catabolic repression and related processes
In: "Gene Manipulation and Expression", (Spivek and Glass eds.) Croom HelM (1985): 255-272

fr A Danchin
Contrôles métaboliques hiérarchisés chez les bactéries
In: Production d'agents thérapeutiques par génie génétique (Ed. A Joyeaux, G Leygue, M Morre, R Roncucci, PH Schmelck) Sanofi Recherche et Medsi/Gower (1985) pp 37-43

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