models vs reality
竹里館

獨坐幽篁里,彈琴復長嘯。
深林人不知,明月來相照。

王維


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La méthode critique générative

Hong Kong Innovation Expo 2001

Created in year 2000 after an idea of Antoine Danchin in 1998, then Chairman of the Institut Pasteur Scientific council, and following negotiations in 1998 and 1999 led by himself and Marie-Françoise Saron, the HKU-Pasteur Research Centre Ltd was created as a joint venture between the Institut Pasteur in Paris and the University of Hong Kong. This vision was presented (in French) at the Scientific council of the Institut Pasteur. A subsequent lack of vision resulted in the dismantlement of the Centre in 2010.

The collaborative project aimed at setting up a laboratory of functional bacterial genomics at Hong Kong University in association with the Institut Pasteur in Paris, combining in vivo and in vitro experiments to in silico analysis of the genomes.

Professor Patrick Yiu-Chung Cheng, Vice-Chancellor of the University of Hong Kong viewed the Centre as the Microbiology pole of the Genome Centre to be created at the University, for the development of genomics in Hong Kong and the region. In order to demonstrate its feasability, the project used two model bacteria Escherichia coli and Bacillus subtilis, together with poorly known counterparts that are important for the control of pathogens and human health and environment, Photorhabdus luminescens and Bacillus cereus (anthracis). These latter bacteria were in addition chosen for their appropriate behaviour under laboratory conditions.

The HKU Pasteur Research Centre Ltd

Functional Genomics

Transcriptomics

Anthrax and its model Bacillus subtilis

Plague, cholera, and Photorhabdus luminescens

 

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