épidémiologie & évolution des maladies infectieuses |
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Contact Recherche Enseignement Divers fr en |
Ma recherche vise à améliorer la compréhension et l'anticipation des dynamiques épidémiologique et évolutive des maladies infectieuses par l'intégration des sources d’hétérogénéité (polymorphisme, structuration spatiale, traitements anti-infectieux, mesures sanitaires) dans l'analyse quantitative multi-niveaux (de l'intra-hôte à la santé publique en passant par la transmission) de pathogènes tels le virus Ebola, les papillomavirus humains, les bactéries multi-résistantes, le SARS-CoV-2. ► Travaux publications internationales • Alizon S & Sofonea MT. (2025) SARS-CoV-2 epidemiology, kinetics, and evolution: a narrative review. • Supplisson O, Tessandier N, Roussel M, Haim-Boukobza S, Burrel S, Sofonea MT, Alizon S. (2025) High-risk human papillomavirus cervical infection prevalence in France, 2020-2023: a nationwide, large-scale, and spatially resolved retrospective study comparing opportunistic and organised screening. • D’Ottavi M, Godfrey-Faussett P, Merle CS, Sofonea MT, Laureillard D, Vickerman P, Molès JP, Altice FL, Van de Perre P, Stone J, Nagot N. Tuberculosis & people who use drugs: why more focus on this overlooked population is important and why adapted interventions are necessary. (2025) • Tessandier N, Élie B, Boué V, Selinger C, Rahmoun M, Bernat C, Grasset S, Groc S, Bedin AS, Bénéteau T, Bonneau M, Graf C, Jacobs N, Kamiya T, Kerioui M, Lajoie J, Melki I, Prétet JL, Reyné B, Schlecht-Louf G, Sofonea MT, Supplisson O, Foulongne V, Guedj J, Hirtz C, Picot MC, Reynes J, Tribout V, Tuaillon É, Waterboer T, Segondy M, Bravo IG, Boulle N, Murall CL, Alizon S. (2025) Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution. • Bénéteau T, Groc S, Murall CL, Boué V, Elie B, Tessandier N, Bernat C, Bonneau M, Foulongne V, Graf C, Grasset S, Rahmoun M, Segondy M, Tribout V, Reynes J, Selinger C, Boulle N, Bravo IG, Sofonea MT, Alizon S. (2024) Incidence and duration of human papillomavirus infections in young women: insights from a bimonthly follow-up cohort. • Hamel R, Narpon Q, Serrato-Pomar I, Gauliard C, Berhtomieu A, Wichit S, Missé D, Sofonea MT, Pompon J. West Nile virus is transmitted within mosquito populations through infectious mosquito excreta. (2024) • Supplisson O, Visseaux B, Haïm-Boukobza S, Boutolleau D, Alizon S, Burrel S, Sofonea MT. (2024) Seroprevalence of human herpesviruses in France, 2018-2022: a multilevel regression and poststratification approach. • Massey A, Boennec C, Restrepo-Ortiz CX, Blanchet C, Alizon S, Sofonea MT. (2024) Real-time forecasting of COVID-19-related hospital strain in France using a non-Markovian mechanistic model. • Fitz-Simon N, Ferguson J, Alvarez-Iglesias A, Sofonea MT, Kamiya T. (2023) Understanding the role of mask-wearing during COVID-19 on the island of Ireland. • Djidjou-Demasse R=, Sofonea MT=, Choisy M, Alizon S. (2023) Within-host evolutionary dynamics of antimicrobial quantitative resistance. • Kamiya T, Alvarez-Iglesias A, Ferguson J, Murphy S, Sofonea MT, Fitz-Simon N. (2023) Estimating time-dependent contact: a multi-strain epidemiological model of SARS-CoV-2 on the island of Ireland. • Boulet N, Boussere A, Mezzarobba M, Sofonea MT, Payen D, Lipman J, Laupland KB, Rello J, Lefrant JY, Muller L, Roger C, Pirracchio R, Mura T, Boudemaghe T. (2023) Intensive Care Unit activity in France from the National database between 2013 and 2019: More critically ill patients, shorter stay and lower mortality rate. • Bessis D, Trouillet-Assant S, Secco LP, Bardin N, Blanc B, Blatière V, Chable-Bessia C, Delfour C, Girard C, Gros N, Le Moing V, Molinari N, Pallure V, Pisoni A, Raison-Peyron N, Reynaud E, Schwob E, Pescarmona R, Samaran Q, Willems M, Vincent T, Sofonea MT, Belot A, Tuaillon E. (2022) COVID-19 pandemic associated chilblains. More link for SARS-CoV-2 and less evidence for high interferon type-1 systemic response. • Sofonea MT, Roquebert B, Foulongne V, Morquin D, Verdurme L, Trombert-Paolantoni S, Roussel M, Bonetti JC, Zerah J, Haim-Boukobza S, Alizon S. (2022) Analyzing and modeling the spread of SARS-CoV-2 Omicron lineages BA.1 and BA.2 in France (September 1, 2021, to February 28, 2022). • Elie B, Lecorche E, Sofonea MT, Trombert-Paolantoni S, Foulongne V, Guedj J, Haim-Boukobza S, Roquebert B, Alizon S. (2021) Inferring SARS-CoV-2 variant within-host kinetics. • Sofonea MT, Cauchemez S, Boëlle PY. (2022) Epidemic models: why and how to use them. • Reyné B, Richard Q, Noûs C, Selinger C=, Sofonea MT=, Djidjou-Demasse R=, Alizon S=. (2022) Non-Markovian modelling highlights the importance of age structure on Covid-19 epidemiological dynamics. • Alizon S, Selinger C=, Sofonea MT=, Haim-Boukobza S, Giannoli JM, Ninove L, Pillet S, Vincent T, de Rougemont A, Tumiotto C, Sollis M, Stephan R, Bressolette-Bodin C, Salmona M, L'Honneur AS, Behillil S, Lefeuvre C, Dina J, Hantz S, Hartard C, Veyer D, Delagreverie HM, Fourati S, Visseaux B, Henquell C, Lina B, Foulongne V, Burrel S. (2022) Epidemiological and clinical insights from SARS-CoV-2 RT-PCR cycle amplification values. • Reyné B, Saby N, Sofonea MT. (2022) Principles of mathematical epidemiology and compartmental modelling application to COVID-19. • Bénéteau T, Elie B, Sofonea MT, Alizon S. (2021) Estimating dates of origin and end of COVID-19 epidemics. • Danesh G, Elie B, Michalakis Y, Sofonea MT, Bal A, Behillil S, Destras G, Boutolleau D, Burrel S, Marcelin A-G, Plantier J-C, Thibault V, Simon-Loriere E, van der Werf S, Lina B, Josset L, Enouf V, Alizon S. (2021) Early phylodynamics analysis of the COVID-19 epidemics in France. • Kuschmierz P and 60 others. (2021) European first-year university students accept evolution but lack substantial knowledge about it: a standardized European cross-country assessment. • Thomine O, Alizon S, Barthelemy M, Boennec C, Sofonea MT. (2021) Emerging dynamics from high-resolution spatial numerical epidemics. • Roquebert B, Haim-Boukobza S, Trombert-Paolantoni S, Lecorche E, Verdurme L, Foulongne V, Burrel S, Alizon S=, Sofonea MT=. (2021) SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France. • Michalakis Y, Sofonea MT, Alizon S, Bravo IG. (2021) SARS-CoV-2 viral RNA levels are not “viral load”. • Sofonea MT & Alizon S (2021) Anticipating COVID-19 intensive care unit capacity strain: A look back at epidemiological projections in France. • Alizon S, Haim-Boukobza S, Foulongne V, Verdurme L, Trombert-Paolantoni S, Lecorche E, Roquebert B, Sofonea MT. (2021) Rapid spread of the SARS-CoV-2 delta variant in French regions in June 2021. • Bénéteau T, Selinger C=, Sofonea MT=, Alizon S=. (2021) Episome partitioning and symmetric cell divisions: quantifying the role of random events in the persistence of HPV infections. • Alizon S & Sofonea MT. (2021) SARS-CoV-2 virulence evolution: avirulence theory, immunity, and trade-offs. • Reyné B, Selinger C, Sofonea MT, Miot S, Pisoni A, Tuaillon E, Bousquet J, Blain H, Alizon S. (2021) Analysing different exposures identifies that wearing masks and establishing COVID-19 areas reduce secondary attack risk in aged care facilities. • Roquebert B, Trombert-Paolantoni S, Haim-Boukobza S, Lecorche E, Verdurme L, Foulongne V, Sofonea MT=, Alizon S=. (2021)The SARS-CoV-2 B.1.351 lineage (VOC β) is outgrowing the B.1.1.7 lineage (VOC α) in some French regions in April 2021. • Sofonea MT, Boennec C, Michalakis Y, Alizon S. (2021) Two waves and a high tide: the COVID-19 epidemic in France. • Sofonea MT, Reyné B, Elie B, Djidjou-Demasse R, Selinger C, Michalakis Y, Alizon S. (2021) Memory is key in capturing COVID-19 epidemiological dynamics. • Haim-Boukobza S, Roquebert B, Trombert-Paolantoni S, Lecorche E, Verdurme L, Foulongne V, Selinger C, Michalakis Y, Sofonea MT=, Alizon S=. (2021) Detecting Rapid Spread of SARS-CoV-2 Variants, France, January 26–February 16, 2021. • Richard Q, Alizon S, Choisy M, Sofonea MT, Djidjou-Demasse R. (2021) Age-structured non-pharmaceutical interventions for optimal control of COVID-19 epidemic. • Djidjou-Demasse R, Alizon S, Sofonea MT. (2021) Within-host bacterial growth dynamics with both mutation and horizontal gene transfer. • Zwart MP, Blanc S, Johnson M, Manrubia S, Michalakis Y, Sofonea MT. (2021) Unresolved advantages of multipartitism in spatially structured environments. • Alizon S, Murall C-L, Saulnier E, Sofonea MT. (2019) Detecting within-host interactions from genotype combination prevalence data. • Sofonea MT. (2019) A global asymptotic
stability condition for a Lotka-Volterra model with indirect
interactions. • Gallet R, Fabre F, Thébaud G, Sofonea MT,
Sicard A, Blanc S, Michalakis Y. (2018) Small bottleneck
size in a highly multipartite virus during a complete
infectious cycle. • Sofonea MT, Aldakak L, Boullosa LF VV, Alizon S. (2018) Can Ebola Virus evolve to be less virulent in
humans? • Sofonea MT, Alizon S, Michalakis Y.
(2017) Exposing the diversity of multiple infection patterns. • Sofonea MT, Alizon S, Michalakis Y.
(2015) From within-host interactions to epidemiological competition: a general model for multiple infections. pré-publications & manuscrits non publiés • Reyné B, Sofonea MT, Alizon S. (2022) Modelling long-term COVID-19 hospital admission dynamics using immune protection waning data. • Verdume L, Danesh G, Trombert S, Sofonea MT, Noel V, Foulongne V, Montès B, Tuaillon E, Haim-Boukobza S, Roquebert B, Alizon S. (2021) Spread of SARS-CoV-2 Delta variant infections bearing the S:E484Q and S:T95I mutations in July and August 2021 in France. • Boennec C, Alizon S, Sofonea MT. Anticipating the hospital burden of future COVID-19 epidemic waves. • Sofonea MT, Boennec C, Fontalirant A, Regnat M, Lefrant JY, Alizon S, Fischer MO. (2021) Quantifying the real-life impacts of vaccination on critical COVID-19. • Reyné B, Danesh G, Alizon S, Sofonea MT. (2020) Rt2: computing and visualising COVID-19 epidemics temporal reproduction number. • Sofonea MT, Reyné B, Elie B, Djidjou-Demasse R, Selinger C, Michalakis Y, Alizon S. (2020) Epidemiological monitoring and control perspectives: application of a parsimonious modelling framework to the COVID-19 dynamics in France. • Djidjou-Demasse R, Michalakis Y, Choisy M, Sofonea MT, Alizon S. (2020) Optimal COVID-19 epidemic control until vaccine deployment. • Sofonea MT, Alizon S, Michalakis Y. (2018)
Why multiple infections favour virulent parasites. francophones • Boulet N, Boussere A, Mezzarobba M, Sofonea MT, Payen D, Lipman J, Laupland KB, Rello J, Lefrant JY, Muller L, Roger C, Pirracchio R, Mura T, Boudemaghe T. (2023) Activité des réanimations françaises à partir d’une base de données nationale entre 2013 et 2019 : une gravité en augmentation, mais des durées de séjour et un taux de mortalité en baisse. • Supplisson O & Sofonea MT. (2023) Pièges et mésusages en analyse de données. • Alizon S & Sofonea MT. (2023) Modélisation mathématique de l’épidémie de Covid-19 en France, et comparaison internationale. • Bessis D, Trouillet-Assant S, Secco LP, Blatière V, Girard C, Molinari N, Pallure V, Raison Peyron N, Schwob E, Pescarmona R, Samaran Q, Vincent T, Sofonea MT, Belot A, Tuaillon E. (2022) Engelures associées au COVID : plus de lien de causalité avec le virus SARS-CoV-2 et moins d’évidence pour une réponse systémique augmentée de l’interféron de type 1. • Djidjou-Demasse R, Selinger C, Sofonea MT. (2020) Épidémiologie mathématique et modélisation de la pandémie de Covid-19 : enjeux et diversité. rapport d'expertise • Le Cann P, Batéjat C, Delache B, Garcia-Verdugo I, Lan Ha T, Leclercq I, Lucet JC, Sofonea MT, Redaelli M, Truffault A, Pernelet-Joly V. (2021) Note d’appui scientifique et technique de l’Anses relatif à la viabilité dans l’air et la dose infectante du virus SARS-COV-2. (saisine n°2021-SA-0018), livres & chapitres • Collectif (sous la direction de Scavée C). (2023) Les années COVID : comment y survivre. • Collectif (sous la direction de Boudeau D, Caudron N, Delorme L, Fabre P, Godard F, Rilhac M, Sicard M, Sofonea MT). (2021) Du labo à la classe : l’évolution en action. • Collectif (sous la direction de Gibert P). (2021) Regards croisés sur les pandémies. protocoles • Beniermann A, Kuschmierz P, Pinxten R, Aivelao T, Bohlin G, Brennecke JS, Cebesoy UB, Cvetković D, Đorđević M, Dvořáková RM, Futo M, Geamana N, Korfiatis K, Lendvai A, Mogias A, Paolucci S, Ptersson M, Pietrzak B, Porozovs J, Realdon G, Savković U, Sofonea MT, Šorgo A, Stermin AN, Torkar G, Uitto A, Vázquez BL, Graf D. (2021) Evolution Education Questionnaire on Acceptance and Knowledge (EEQ) - Standardised and ready-to-use protocols to measure acceptance of evolution and knowledge about evolution in an international context. mémoires • Sofonea MT (2024) Analyses quantitatives par temps de crise sanitaire. HDR. • Sofonea MT. (2017) Évolution de la virulence et infections multiples. PhD.
• Sofonea MT, Reyné B, Alizon S. (2020) COVIDSIM – Combining statistical analysis of hospital data and parsimonious non Markovian modelling for infering epidemiological parameters and simulating NPI of the COVID-19 epidemic in France. • Reyné B, Danesh G, Alizon S, Sofonea MT. (2020) Rt2 – Estimating the reproduction number of COVID-19 epidemics in different countries and, for France, in regions and departments using incidence, hosptialisation, and mortality data. • Boennec C, Alizon S, Sofonea MT. (2021) COVIDici – Visualization & projection tool of the COVID-19 populational data in France at national, regional and departmental levels. • Boennec C, Sofonea MT, Alizon S. (2021) COVimpact – Estimating the residual hospital impact of COVID-19 in France.
• Membre du Comité de Direction de la Fédération Hospitalo-Universitaire TIE (CHU de Montpellier) (depuis 2022)
• Thomas Beneteau (Ligue contre le Cancer, 2019 - 2023) |