Allele frequency change covariances in time series

Estimating the contribution of admixture, selection, and genetic drift to allele frequency change in time series genomic data.

Following Buffalo and Coop (2019) and Buffalo and Coop (2020), we are interested in investigating scenarios of time series with admixture.

Similarly to linked selection, admixture is expected to create non-zero covariances between allele frequency changes. Can we correct for this and quantify its effects?

Our goal is to use human ancient DNA datasets as time transects where we know admixture has happened (e.g. in Europe).


Buffalo, Vince, and Graham Coop. 2019. “The Linked Selection Signature of Rapid Adaptation in Temporal Genomic Data.” Genetics 213: 1007–45.
———. 2020. “Estimating the Genome-Wide Contribution of Selection to Temporal Allele Frequency Change.” Proceedings of the National Academy of Sciences 117 (34): 20672–80.