My research aims to improve the understanding and the anticipation of the epidemiological and evolutionary dynamics of infectious diseases by integrating sources of heterogeneity (polymorphism, spatial structuring, anti-infective treatments, health policies) in the multi-level quantitative analysis (from intra-host to public health via transmission) of pathogens such as Ebola virus, human papillomaviruses, multidrug-resistant bacteria, and more recently SARS-CoV-2.

   international publications

• Reyné B, Saby N, Sofonea MT. (2021) Principles of mathematical epidemiology and compartmental modelling application to COVID-19. Anaesth Crit Care Pain Med [link]

• Djidjou-Demasse R⁼, Sofonea MT⁼, Choisy M, Alizon S. (2021) Within-host evolutionary dynamics of antimicrobial quantitative resistance. PCI Math Comp Biol [pdf]

• Danesh G, Elie B, Michalakis Y, Sofonea MT, Bal A, Behillil S, Destras G, Boutolleau D, Burrel S, Marcelin A-G, Plantier J-C, Thibault V, Simon-Loriere E, van der Werf S, Lina B, Josset L, Enouf V, Alizon S. (2021) Early phylodynamics analysis of the COVID-19 epidemics in France. Peer Community Journal [pdf]

• Kuschmierz P and 60 others. (2021) European first-year university students accept evolution but lack substantial knowledge about it: a standardized European cross-country assessment. Evo Edu Outreach [link]

• Alizon S, Selinger C⁼, Sofonea MT⁼, Haim-Boukobza S, Giannoli JM, Ninove L, Pillet S, Vincent T, de Rougemont A, Tumiotto C, Sollis M, Stephan R, Bressolette-Bodin C, Salmona M, L'Honneur AS, Behillil S, Lefeuvre C, Dina J, Hantz S, Hartard C, Veyer D, Delagreverie HM, Fourati S, Visseaux B, Henquell C, Lina B, Foulongne V, Burrel S (2021) Epidemiological and clinical insights from SARS-CoV-2 RT-PCR cycle amplification values. Eurosurveillance [in press]

• Thomine O, Alizon S, Barthelemy M, Boennec C, Sofonea MT. (2021) Emerging dynamics from high-resolution spatial numerical epidemics. eLife [link]

• Roquebert B, Haim-Boukobza S, Trombert-Paolantoni S, Lecorche E, Verdurme L, Foulongne V, Burrel S, Alizon S⁼, Sofonea MT⁼. (2021) SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France. Int J Infect Dis [in press]

• Michalakis Y, Sofonea MT, Alizon S, Bravo IG. (2021) SARS-CoV-2 viral RNA levels are not “viral load”. Trends Microbiol [link]

• Sofonea MT & Alizon S (2021) Anticipating COVID-19 intensive care unit capacity strain: A look back at epidemiological projections in France. Anaesth Crit Care Pain Med [link ]

• Bénéteau T, Elie B, Sofonea MT, Alizon S. (2021) Estimating dates of origin and end of COVID-19 epidemics. PCI Math Comp Biol [pdf]

• Alizon S, Haim-Boukobza S, Foulongne V, Verdurme L, Trombert-Paolantoni S, , Lecorche E, Roquebert B, Sofonea MT. (2021) Rapid spread of the SARS-CoV-2 delta variant in French regions in June 2021. Eurosurveillance [link]

• Bénéteau T, Selinger C⁼, Sofonea MT⁼, Alizon S⁼. (2021) Episome partitioning and symmetric cell divisions: quantifying the role of random events in the persistence of HPV infections. PLoS Comput Biol [in press]

• Alizon S & Sofonea MT. (2021) SARS-CoV-2 virulence evolution: avirulence theory, immunity, and trade-offs. J Evol Biol [pdf]

• Reyné B, Selinger C, Sofonea MT, Miot S, Pisoni A, Tuaillon E, Bousquet J, Blain H, Alizon S. (2021) Analysing different exposures identifies that wearing masks and establishing COVID-19 areas reduce secondary attack risk in aged care facilities. Int J Epidemiol [pdf]

• Roquebert B, Trombert-Paolantoni S, Haim-Boukobza S, Lecorche E, Verdurme L, Foulongne V, Sofonea MT⁼, Alizon S⁼. (2021)The SARS-CoV-2 B.1.351 lineage (VOC β) is outgrowing the B.1.1.7 lineage (VOC α) in some French regions in April 2021. Eurosurveillance [pdf]

• Sofonea MT, Boennec C, Michalakis Y, Alizon S. (2021) Two waves and a high tide: the COVID-19 epidemic in France. Anaesth Crit Care Pain Med [link]

• Sofonea MT, Reyné B, Elie B, Djidjou-Demasse R, Selinger C, Michalakis Y, Alizon S. (2021) Memory is key in capturing COVID-19 epidemiological dynamics. Epidemics [lien]

• Haim-Boukobza S, Roquebert B, Trombert-Paolantoni S, Lecorche E, Verdurme L, Foulongne V, Selinger C, Michalakis Y, Sofonea MT⁼, Alizon S⁼. (2021) Detecting Rapid Spread of SARS-CoV-2 Variants, France, January 26–February 16, 2021. Emerg Infect Dis 10.3201/eid2705.210397 [pdf]

• Richard Q, Alizon S, Choisy M, Sofonea MT, Djidjou-Demasse R. (2021) Age-structured non-pharmaceutical interventions for optimal control of COVID-19 epidemic. PLoS Comput Biol 17(3):e1008776 [link]

• Djidjou-Demasse R, Alizon S, Sofonea MT. (2021) Within-host bacterial growth dynamics with both mutation and horizontal gene transfer. J Math Biol 82, 16. [pdf]

• Zwart MP, Blanc S, Johnson M, Manrubia S, Michalakis Y, Sofonea MT. (2021) Unresolved advantages of multipartitism in spatially structured environments. Virus Evol 7(1): veab004. [link]

• Alizon S, Murall C-L, Saulnier E, Sofonea MT. (2019) Detecting within-host interactions from genotype combination prevalence data. Epidemics 29: 100349 [pdf]

• Sofonea MT. (2019) A global asymptotic stability condition for a Lotka-Volterra model with indirect interactions. Applicable Analysis 98(9), 1636-1645 [pdf]

• Gallet R, Fabre F, Thébaud G, Sofonea MT, Sicard A, Blanc S, Michalakis Y. (2018) Small bottleneck size in a highly multipartite virus during a complete infectious cycle. J Virol 92(14) [pdf]

• Sofonea MT, Aldakak L, Boullosa LF VV, Alizon S. (2018) Can Ebola Virus evolve to be less virulent in humans? J Evol Biol 31 (3), 382-392 [pdf] [sm]

• Sofonea MT, Alizon S, Michalakis Y. (2017) Exposing the diversity of multiple infection patterns. J Theor Biol 419: 278--289. [pdf] [sm]

• Sofonea MT, Alizon S, Michalakis Y. (2015) From within-host interactions to epidemiological competition: a general model for multiple infections. Phil Trans R Soc B 370(1675): 20140303. [pdf] [sm]

   preprints

• Sofonea MT, Roquebert B, Foulongne V, Verdurme L, Trombert-Paolantoni S, Roussel M, Haim-Boukobza S, Alizon S. (2022) From Delta to Omicron: analysing the SARS-CoV-2 epidemic in France using variant-specific screening tests (September 1 to December 18, 2021) medRxiv [pdf]

• Reyné B, Richard Q, Noûs C, Selinger C⁼, Sofonea MT⁼, Djidjou-Demasse R⁼, Alizon S⁼. (2021) The importance of the population age-structure: insights from Covid-19 dynamics model structured by age, time since infection and acquired immunity. medRxiv [pdf]

• Verdume L, Danesh G, Trombert S, Sofonea MT, Noel V, Foulongne V, Montès B, Tuaillon E, Haim-Boukobza S, Roquebert B, Alizon S. (2021) Spread of SARS-CoV-2 Delta variant infections bearing the S:E484Q and S:T95I mutations in July and August 2021 in France medRxiv [pdf]

• Boennec C, Alizon S, Sofonea MT. Anticipating the hospital burden of future COVID-19 epidemic waves medRxiv [pdf].

• Sofonea MT, Boennec C, Fontalirant A, Regnat M, Lefrant JY, Alizon S, Fischer MO. (2021) Quantifying the real-life impacts of vaccination on critical COVID-19 OSF [pdf]

• Elie B, Lecorche E, Sofonea MT, Trombert-Paolantoni S, Foulongne V, Guedj J, Haim-Boukobza S, Roquebert B, Alizon S. (2021) Inferring SARS-CoV-2 variant within-host kinetics. medRxiv [pdf

• Reyné B, Danesh G, Alizon S, Sofonea MT. (2020) Rt2: computing and visualising COVID-19 epidemics temporal reproduction number. medRxiv [pdf]

• Sofonea MT, Reyné B, Elie B, Djidjou-Demasse R, Selinger C, Michalakis Y, Alizon S. (2020) Epidemiological monitoring and control perspectives: application of a parsimonious modelling framework to the COVID-19 dynamics in France. medRxiv [pdf]

• Djidjou-Demasse R, Michalakis Y, Choisy M, Sofonea MT, Alizon S. (2020) Optimal COVID-19 epidemic control until vaccine deployment. medRxiv [pdf]

• Sofonea MT, Alizon S, Michalakis Y. (2018) Why multiple infections favour virulent parasites. bioRxiv [pdf][som]

   French publications

• Djidjou-Demasse R, Selinger C, Sofonea MT. (2020) Épidémiologie mathématique et modélisation de la pandémie de Covid-19 : enjeux et diversité. Revue Francophone des Laboratoires [lien]

   expert report

• Anses. (2021) Note d'appui scientifique et technique relative à la viabilité dans l'air et la dose infectante du virus SARS-CoV-2. (saisine 2021-SA-0018). Maisons-Alfort : Anses, 101 p [pdf] (in French)

   books

   protocoles

• Beniermann A, Kuschmierz P, Pinxten R, Aivelao T, Bohlin G, Brennecke JS, Cebesoy UB, Cvetković D, Đorđević M, Dvořáková RM, Futo M, Geamana N, Korfiatis K, Lendvai A, Mogias A, Paolucci S, Ptersson M, Pietrzak B, Porozovs J, Realdon G, Savković U, Sofonea MT, Šorgo A, Stermin AN, Torkar G, Uitto A, Vázquez BL, Graf D. (2021) Evolution Education Questionnaire on Acceptance and Knowledge (EEQ) - Standardised and ready-to-use protocols to measure acceptance of evolution and knowledge about evolution in an international context Zenodo [link]

   thesis

• Sofonea MT (2017) Virulence evolution and multiple infections. PhD thesis in evolution of infectious systems. [pdf]

► Softwares

• Sofonea MT, Reyné B, Alizon S. (2020) COVIDSIM – Combining statistical analysis of hospital data and parsimonious non Markovian modelling for infering epidemiological parameters and simulating NPI of the COVID-19 epidemic in France. i-Trop bioinformatics [link]

• Reyné B, Danesh G, Alizon S, Sofonea MT. (2020) Rt2 – Estimating the reproduction number of COVID-19 epidemics in different countries and, for France, in regions and departments using incidence, hosptialisation, and mortality data. France Bioinformatique [link]

• Boennec C, Alizon S, Sofonea MT. (2021) COVIDici – Visualization & projection tool of the COVID-19 populational data in France at national, regional and departmental levels. France Bioinformatique [link]

► Responsibilities

• Guest Editor of Anaesthesia Critical Care and Pain Medicine (2021)
• Membre of the Modelling Coordinated Action of the ANRS|MIE (since 2021)
• Member of the Air & COVID expert group of the ANSES (since 2021)
• Head of the Theoretical & Experimental Evolution research group (MIVEGEC - Univ. Montpellier, CNRS, IRD - since 2021)
• Member of the modelling & evolutionary ecology expert panel of Arbo-France (French network for the study of arboviroses) (since 2020)
• PhD grant reviewer (ENS, Paris, since 2019)
• member of the organizing committee of the Evolution 2018 congress (Montpellier, 2016 - 2018)

► Co-supervision of Phd theses

• Thomas Beneteau (Ligue nationale contre le Cancer grant, 2019 - )
• Bastien Reyné (French Doctoral School grant, 2020 - )

► Co-supervision of Master internships

• Thomas Beneteau (M2 AgroParisTech, 2019)
• Julien Lombard (M1 Rennes, 2019)
• Luis F.V.V. Boullosa (M1 international MEME 2016)
• Lafi Aldakak (M1 international MEME, 2015)

► International communications

54 invitations, 9 selected talks