My research aims to improve the understanding and the anticipation of the epidemiological and evolutionary dynamics of infectious diseases by integrating sources of heterogeneity (polymorphism, spatial structuring, anti-infective treatments, health policies) in the multi-level quantitative analysis (from intra-host to public health via transmission) of pathogens such as Ebola virus, human papillomaviruses, multidrug-resistant bacteria, and more recently SARS-CoV-2.

   international publications

• Roxon J, Dumont MS, Vilain E, Sofonea MT, Pellenq RJM. (2025) Urban Environmental and Population Factors as Determinants of COVID-19 Severity: A Spatially-Resolved Probabilistic Modeling Approach PLOS Digit Health.

• Reyné B, Djidjou-Demasse R⁼, Sofonea MT⁼, Alizon S⁼. (2025) Mutant emergence timing and population immunisation status impact epidemiological dynamics. J Theor Biol.

• D'Ottavi M, Thi Tran H, Nguyen H, Hai Vu V, Tanh Binh N, Quang Nguyen D, Bach Thi Nhu Q, Tuyet Thi Nham T, Thi Hai Khuat O, Stone J, Walker J, Sofonea MT, Blanc FX, Bonneton M, Laureillard D, Molès JP, Minh Khue P, Thi Duong H, Nagot N. (2025) What Is the Optimal Community-Based Tuberculosis Screening Algorithm for People Who Inject Drugs in a High-Burden Setting? Open Forum Infect Dis.

• Alizon S & Sofonea MT. (2025) SARS-CoV-2 epidemiology, kinetics, and evolution: a narrative review. Virulence.

• Supplisson O, Tessandier N, Roussel M, Haim-Boukobza S, Burrel S, Sofonea MT, Alizon S. (2025) High-risk human papillomavirus cervical infection prevalence in France, 2020-2023: a nationwide, large-scale, and spatially resolved retrospective study comparing opportunistic and organised screening. Eurosurveillance.

• D’Ottavi M, Godfrey-Faussett P, Merle CS, Sofonea MT, Laureillard D, Vickerman P, Molès JP, Altice FL, Van de Perre P, Stone J, Nagot N. Tuberculosis & people who use drugs: why more focus on this overlooked population is important and why adapted interventions are necessary. (2025) Lancet Global Health.

• Tessandier N, Élie B, Boué V, Selinger C, Rahmoun M, Bernat C, Grasset S, Groc S, Bedin AS, Bénéteau T, Bonneau M, Graf C, Jacobs N, Kamiya T, Kerioui M, Lajoie J, Melki I, Prétet JL, Reyné B, Schlecht-Louf G, Sofonea MT, Supplisson O, Foulongne V, Guedj J, Hirtz C, Picot MC, Reynes J, Tribout V, Tuaillon É, Waterboer T, Segondy M, Bravo IG, Boulle N, Murall CL, Alizon S. (2025) Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution. PLOS Biol.

• Bénéteau T, Groc S, Murall CL, Boué V, Elie B, Tessandier N, Bernat C, Bonneau M, Foulongne V, Graf C, Grasset S, Rahmoun M, Segondy M, Tribout V, Reynes J, Selinger C, Boulle N, Bravo IG, Sofonea MT, Alizon S. (2024) Incidence and duration of human papillomavirus infections in young women: insights from a bimonthly follow-up cohort. Infect Dis.

• Hamel R, Narpon Q, Serrato-Pomar I, Gauliard C, Berhtomieu A, Wichit S, Missé D, Sofonea MT, Pompon J. West Nile virus is transmitted within mosquito populations through infectious mosquito excreta. (2024) iScience.

• Supplisson O, Visseaux B, Haïm-Boukobza S, Boutolleau D, Alizon S, Burrel S, Sofonea MT. (2024) Seroprevalence of human herpesviruses in France, 2018-2022: a multilevel regression and poststratification approach. Infect Dis.

• Massey A, Boennec C, Restrepo-Ortiz CX, Blanchet C, Alizon S, Sofonea MT. (2024) Real-time forecasting of COVID-19-related hospital strain in France using a non-Markovian mechanistic model. PLOS Comp Biol.

• Fitz-Simon N, Ferguson J, Alvarez-Iglesias A, Sofonea MT, Kamiya T. (2023) Understanding the role of mask-wearing during COVID-19 on the island of Ireland. Royal Soc Open Sci.

• Djidjou-Demasse R⁼, Sofonea MT⁼, Choisy M, Alizon S. (2023) Within-host evolutionary dynamics of antimicrobial quantitative resistance. Math Model Nat Phenom.

• Kamiya T, Alvarez-Iglesias A, Ferguson J, Murphy S, Sofonea MT, Fitz-Simon N. (2023) Estimating time-dependent contact: a multi-strain epidemiological model of SARS-CoV-2 on the island of Ireland. Global Epidemiology.

• Boulet N, Boussere A, Mezzarobba M, Sofonea MT, Payen D, Lipman J, Laupland KB, Rello J, Lefrant JY, Muller L, Roger C, Pirracchio R, Mura T, Boudemaghe T. (2023) Intensive Care Unit activity in France from the National database between 2013 and 2019: More critically ill patients, shorter stay and lower mortality rate. Anaesth Crit Care Pain Med.

• Bessis D, Trouillet-Assant S, Secco LP, Bardin N, Blanc B, Blatière V, Chable-Bessia C, Delfour C, Girard C, Gros N, Le Moing V, Molinari N, Pallure V, Pisoni A, Raison-Peyron N, Reynaud E, Schwob E, Pescarmona R, Samaran Q, Willems M, Vincent T, Sofonea MT, Belot A, Tuaillon E. (2022) COVID-19 pandemic associated chilblains. More link for SARS-CoV-2 and less evidence for high interferon type-1 systemic response. Br J Dermatol.

• Sofonea MT, Roquebert B, Foulongne V, Morquin D, Verdurme L, Trombert-Paolantoni S, Roussel M, Bonetti JC, Zerah J, Haim-Boukobza S, Alizon S. (2022) Analyzing and modeling the spread of SARS-CoV-2 Omicron lineages BA.1 and BA.2 in France (September 1, 2021, to February 28, 2022). Emerg Infect Dis.

• Elie B, Lecorche E, Sofonea MT, Trombert-Paolantoni S, Foulongne V, Guedj J, Haim-Boukobza S, Roquebert B, Alizon S. (2021) Inferring SARS-CoV-2 variant within-host kinetics. J Med Virol.

• Sofonea MT, Cauchemez S, Boëlle PY. (2022) Epidemic models: why and how to use them. Anaesth Crit Care Pain Med.

• Reyné B, Richard Q, Noûs C, Selinger C⁼, Sofonea MT⁼, Djidjou-Demasse R⁼, Alizon S⁼. (2022) Non-Markovian modelling highlights the importance of age structure on Covid-19 epidemiological dynamics. Math Model Nat Phenom.

• Alizon S, Selinger C⁼, Sofonea MT⁼, Haim-Boukobza S, Giannoli JM, Ninove L, Pillet S, Vincent T, de Rougemont A, Tumiotto C, Sollis M, Stephan R, Bressolette-Bodin C, Salmona M, L'Honneur AS, Behillil S, Lefeuvre C, Dina J, Hantz S, Hartard C, Veyer D, Delagreverie HM, Fourati S, Visseaux B, Henquell C, Lina B, Foulongne V, Burrel S. (2022) Epidemiological and clinical insights from SARS-CoV-2 RT-PCR cycle amplification values. Eurosurveillance.

• Reyné B, Saby N, Sofonea MT. (2022) Principles of mathematical epidemiology and compartmental modelling application to COVID-19. Anaesth Crit Care Pain Med.

• Bénéteau T, Elie B, Sofonea MT, Alizon S. (2021) Estimating dates of origin and end of COVID-19 epidemics. Peer Community Journal.

• Danesh G, Elie B, Michalakis Y, Sofonea MT, Bal A, Behillil S, Destras G, Boutolleau D, Burrel S, Marcelin A-G, Plantier J-C, Thibault V, Simon-Loriere E, van der Werf S, Lina B, Josset L, Enouf V, Alizon S. (2021) Early phylodynamics analysis of the COVID-19 epidemics in France. Peer Community Journal.

• Kuschmierz P and 60 others. (2021) European first-year university students accept evolution but lack substantial knowledge about it: a standardized European cross-country assessment. Evo Edu Outreach.

• Thomine O, Alizon S, Barthelemy M, Boennec C, Sofonea MT. (2021) Emerging dynamics from high-resolution spatial numerical epidemics. eLife.

• Roquebert B, Haim-Boukobza S, Trombert-Paolantoni S, Lecorche E, Verdurme L, Foulongne V, Burrel S, Alizon S⁼, Sofonea MT⁼. (2021) SARS-CoV-2 variants of concern are associated with lower RT-PCR amplification cycles between January and March 2021 in France. Int J Infect Dis.

• Michalakis Y, Sofonea MT, Alizon S, Bravo IG. (2021) SARS-CoV-2 viral RNA levels are not “viral load”. Trends Microbiol.

• Sofonea MT & Alizon S (2021) Anticipating COVID-19 intensive care unit capacity strain: A look back at epidemiological projections in France. Anaesth Crit Care Pain Med.

• Alizon S, Haim-Boukobza S, Foulongne V, Verdurme L, Trombert-Paolantoni S, Lecorche E, Roquebert B, Sofonea MT. (2021) Rapid spread of the SARS-CoV-2 delta variant in French regions in June 2021. Eurosurveillance.

• Bénéteau T, Selinger C⁼, Sofonea MT⁼, Alizon S⁼. (2021) Episome partitioning and symmetric cell divisions: quantifying the role of random events in the persistence of HPV infections. PLOS Comput Biol.

• Alizon S & Sofonea MT. (2021) SARS-CoV-2 virulence evolution: avirulence theory, immunity, and trade-offs. J Evol Biol.

• Reyné B, Selinger C, Sofonea MT, Miot S, Pisoni A, Tuaillon E, Bousquet J, Blain H, Alizon S. (2021) Analysing different exposures identifies that wearing masks and establishing COVID-19 areas reduce secondary attack risk in aged care facilities. Int J Epidemiol.

• Roquebert B, Trombert-Paolantoni S, Haim-Boukobza S, Lecorche E, Verdurme L, Foulongne V, Sofonea MT⁼, Alizon S⁼. (2021)The SARS-CoV-2 B.1.351 lineage (VOC β) is outgrowing the B.1.1.7 lineage (VOC α) in some French regions in April 2021. Eurosurveillance.

• Sofonea MT, Boennec C, Michalakis Y, Alizon S. (2021) Two waves and a high tide: the COVID-19 epidemic in France. Anaesth Crit Care Pain Med.

• Sofonea MT, Reyné B, Elie B, Djidjou-Demasse R, Selinger C, Michalakis Y, Alizon S. (2021) Memory is key in capturing COVID-19 epidemiological dynamics. Epidemics.

• Haim-Boukobza S, Roquebert B, Trombert-Paolantoni S, Lecorche E, Verdurme L, Foulongne V, Selinger C, Michalakis Y, Sofonea MT⁼, Alizon S⁼. (2021) Detecting Rapid Spread of SARS-CoV-2 Variants, France, January 26–February 16, 2021. Emerg Infect Dis.

• Richard Q, Alizon S, Choisy M, Sofonea MT, Djidjou-Demasse R. (2021) Age-structured non-pharmaceutical interventions for optimal control of COVID-19 epidemic. PLOS Comput Biol.

• Djidjou-Demasse R, Alizon S, Sofonea MT. (2021) Within-host bacterial growth dynamics with both mutation and horizontal gene transfer. J Math Biol.

• Zwart MP, Blanc S, Johnson M, Manrubia S, Michalakis Y, Sofonea MT. (2021) Unresolved advantages of multipartitism in spatially structured environments. Virus Evol.

• Alizon S, Murall C-L, Saulnier E, Sofonea MT. (2019) Detecting within-host interactions from genotype combination prevalence data. Epidemics.

• Sofonea MT. (2019) A global asymptotic stability condition for a Lotka-Volterra model with indirect interactions. Applicable Analysis.

• Gallet R, Fabre F, Thébaud G, Sofonea MT, Sicard A, Blanc S, Michalakis Y. (2018) Small bottleneck size in a highly multipartite virus during a complete infectious cycle. J Virol.

• Sofonea MT, Aldakak L, Boullosa LF VV, Alizon S. (2018) Can Ebola Virus evolve to be less virulent in humans? J Evol Biol.

• Sofonea MT, Alizon S, Michalakis Y. (2017) Exposing the diversity of multiple infection patterns. J Theor Biol.

• Sofonea MT, Alizon S, Michalakis Y. (2015) From within-host interactions to epidemiological competition: a general model for multiple infections. Phil Trans R Soc B.

   preprints & unpublished manuscripts

• Reyné B, Sofonea MT, Alizon S. (2022) Modelling long-term COVID-19 hospital admission dynamics using immune protection waning data. medRxiv.

• Verdume L, Danesh G, Trombert S, Sofonea MT, Noel V, Foulongne V, Montès B, Tuaillon E, Haim-Boukobza S, Roquebert B, Alizon S. (2021) Spread of SARS-CoV-2 Delta variant infections bearing the S:E484Q and S:T95I mutations in July and August 2021 in France. medRxiv.

• Boennec C, Alizon S, Sofonea MT. Anticipating the hospital burden of future COVID-19 epidemic waves. medRxiv.

• Sofonea MT, Boennec C, Fontalirant A, Regnat M, Lefrant JY, Alizon S, Fischer MO. (2021) Quantifying the real-life impacts of vaccination on critical COVID-19. OSF.

• Reyné B, Danesh G, Alizon S, Sofonea MT. (2020) Rt2: computing and visualising COVID-19 epidemics temporal reproduction number. medRxiv.

• Sofonea MT, Reyné B, Elie B, Djidjou-Demasse R, Selinger C, Michalakis Y, Alizon S. (2020) Epidemiological monitoring and control perspectives: application of a parsimonious modelling framework to the COVID-19 dynamics in France. medRxiv.

• Djidjou-Demasse R, Michalakis Y, Choisy M, Sofonea MT, Alizon S. (2020) Optimal COVID-19 epidemic control until vaccine deployment. medRxiv.

• Sofonea MT, Alizon S, Michalakis Y. (2018) Why multiple infections favour virulent parasites. bioRxiv.

   French publications

• Picard R, Augusto V, Béjean M, Bertrand A, Bicout D, Bonneterre V, Castells B, Didry J, Dron JC, Bakali El Kassimi A, Facchi G, Fourneyron E, Garaix T, Garnier V, Guerder F, Harbouche M, Heintz D, Husson FA, Jacquemin B, Jeanson F, Kervadec M, Laplanche D, Laune D, Levet P, Maître X, Massart S, Mercier G, Noël PY, Olympie A, Pécuchet N, Petit P, Poumarède B, Poupaud M, Prague M, Quesnel-Barbet A, Rodts U, Samson M, Siess V, Sofonea MT, Thiébaut R, Traynard PY, Uhl L, Versini F, Xie X, Zanotti W, Berrut G, Blain H, Sibilia J, Bousquet J. (2025) Ambitions et principaux enseignements du colloque « Santé globale, décisions locales », organisé par la Filière Santé numérique. Gériatrie et Psychologie Neuropsychiatrie du Vieillissement.

• Hamel R, Sofonea MT, Pompon J. (2025) Un nouveau mode de transmission du virus du Nil occidental dans les populations de moustiques mis à jour. Virologie.

• Boulet N, Boussere A, Mezzarobba M, Sofonea MT, Payen D, Lipman J, Laupland KB, Rello J, Lefrant JY, Muller L, Roger C, Pirracchio R, Mura T, Boudemaghe T. (2023) Activité des réanimations françaises à partir d’une base de données nationale entre 2013 et 2019 : une gravité en augmentation, mais des durées de séjour et un taux de mortalité en baisse. Anesthésie & Réanimation..

• Supplisson O & Sofonea MT. (2023) Pièges et mésusages en analyse de données. Anesthésie & Réanimation.

• Alizon S & Sofonea MT. (2023) Modélisation mathématique de l’épidémie de Covid-19 en France, et comparaison internationale. Annales des Mines -- Enjeux numériques..

• Bessis D, Trouillet-Assant S, Secco LP, Blatière V, Girard C, Molinari N, Pallure V, Raison Peyron N, Schwob E, Pescarmona R, Samaran Q, Vincent T, Sofonea MT, Belot A, Tuaillon E. (2022) Engelures associées au COVID : plus de lien de causalité avec le virus SARS-CoV-2 et moins d’évidence pour une réponse systémique augmentée de l’interféron de type 1. Annales de Dermatologie et de Vénérologie - FMC.

• Djidjou-Demasse R, Selinger C, Sofonea MT. (2020) Épidémiologie mathématique et modélisation de la pandémie de Covid-19 : enjeux et diversité. Revue Francophone des Laboratoires.

   expert report

• Le Cann P, Batéjat C, Delache B, Garcia-Verdugo I, Lan Ha T, Leclercq I, Lucet JC, Sofonea MT, Redaelli M, Truffault A, Pernelet-Joly V. (2021) Note d’appui scientifique et technique de l’Anses relatif à la viabilité dans l’air et la dose infectante du virus SARS-COV-2. (saisine n°2021-SA-0018), Anses.

   books & chapters

• Collective work (edited by Scavée C). (2023) Les années COVID : comment y survivre. Rue de Seine Éditions.

• Collective work (edited by Boudeau D, Caudron N, Delorme L, Fabre P, Godard F, Rilhac M, Sicard M, Sofonea MT). (2021) Du labo à la classe : l’évolution en action. APBG.

• Collective work (edited by Gibert P). (2021) Regards croisés sur les pandémies. CNRS Éditions.

   protocoles

• Beniermann A, Kuschmierz P, Pinxten R, Aivelao T, Bohlin G, Brennecke JS, Cebesoy UB, Cvetković D, Đorđević M, Dvořáková RM, Futo M, Geamana N, Korfiatis K, Lendvai A, Mogias A, Paolucci S, Ptersson M, Pietrzak B, Porozovs J, Realdon G, Savković U, Sofonea MT, Šorgo A, Stermin AN, Torkar G, Uitto A, Vázquez BL, Graf D. (2021) Evolution Education Questionnaire on Acceptance and Knowledge (EEQ) - Standardised and ready-to-use protocols to measure acceptance of evolution and knowledge about evolution in an international context. Zenodo.

   theses

• Sofonea MT (2024) Quantitative analyses in times of health crisis. HDR. Sorbonne Univ. - Medicine. [video]

• Sofonea MT (2017) Virulence evolution and multiple infections. PhD. Univ. Montpellier.

► Softwares

• Sofonea MT, Reyné B, Alizon S. (2020) COVIDSIM – Combining statistical analysis of hospital data and parsimonious non Markovian modelling for infering epidemiological parameters and simulating NPI of the COVID-19 epidemic in France. i-Trop bioinformatics.

• Reyné B, Danesh G, Alizon S, Sofonea MT. (2020) Rt2 – Estimating the reproduction number of COVID-19 epidemics in different countries and, for France, in regions and departments using incidence, hosptialisation, and mortality data. France Bioinformatique.

• Boennec C, Alizon S, Sofonea MT. (2021) COVIDici – Visualization & projection tool of the COVID-19 populational data in France at national, regional and departmental levels. France Bioinformatique.

• Boennec C, Sofonea MT, Alizon S. (2021) COVimpact – Estimating the residual hospital impact of COVID-19 in France. France Bioinformatique.

► Responsibilities

• Member of the Steering Commitee of the TIE University-Hospital Federation (University Hospital of Montpellier) (since 2023)
• Research head of the Exposome Institute of the University of Montpellier (ExposUM) (since 2022)
• Associate Editor of Anaesthesia Critical Care and Pain Medicine (since 2021)
• Executive Member of the Modelling Coordinated Action of the ANRS|MIE (since 2021)
• Member of the Air & COVID expert group of the ANSES (2021)
• Head of the Theoretical & Experimental Evolution research group (MIVEGEC - Univ. Montpellier, CNRS, IRD - 2021-2022)
• Member of the modelling & evolutionary ecology expert panel of Arbo-France (French network for the study of arboviroses) (since 2020)
• PhD grant reviewer (ENS, Paris, since 2019)
• Member of the organizing committee of the Evolution 2018 congress (Montpellier, 2016 - 2018)

► Co-supervision of Phd theses

• Thomas Beneteau (Ligue nationale contre le Cancer grant, 2019 - 2023)
• Bastien Reyné (Doctoral School grant, 2020 - 2023)
• Olivier Supplisson (ANRS|MIE grant, 2022 - 2025)
• Morgana D'Ottavi (Doctoral School grant, 2022 - 2025)
• Ana Guijarro Matos (ExposUM Nexus, 2024 - 2028)