Allele frequency change covariances in time series

Estimating the contribution of admixture, selection, and genetic drift to allele frequency change in time series genomic data.
past

I developed a theoretical model designed to estimate the genome-wide contribution of linked selection with temporal data. I included the effect of gene flow in the model, important for natural populations. Then, I used human ancient DNA as time points. In contrast with the expected selection and background selection in humans, I detected no linked selection, only drift and gene flow.

This work was published in Simon and Coop (2024).

References

Simon, Alexis, and Graham Coop. 2024. “The Contribution of Gene Flow, Selection, and Genetic Drift to Five Thousand Years of Human Allele Frequency Change.” Proceedings of the National Academy of Sciences 121 (9): e2312377121. https://doi.org/10.1073/pnas.2312377121.